HCSGD entry for DNA2

1. General information

Official gene symbolDNA2
Entrez ID1763
Gene full nameDNA replication helicase/nuclease 2
Other gene symbolsDNA2L PEOA6 hDNA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000076DNA replication checkpointIMPbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000722Telomere maintenance via recombinationTASbiological_process
GO:0000723Telomere maintenanceTASbiological_process
GO:0000729DNA double-strand break processingIDAbiological_process
GO:0000737DNA catabolic process, endonucleolyticIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003678DNA helicase activityIDAmolecular_function
GO:0004386Helicase activityTASmolecular_function
GO:0004518Nuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005760Gamma DNA polymerase complexIDAcellular_component
GO:0006200ATP catabolic processIDA TASbiological_process
GO:0006260DNA replicationIMPbiological_process
GO:0006264Mitochondrial DNA replicationIDAbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0006284Base-excision repairIDAbiological_process
GO:0016887ATPase activityTASmolecular_function
GO:0016890Site-specific endodeoxyribonuclease activity, specific for altered baseIDAmolecular_function
GO:00171085'-flap endonuclease activityIDA IEAmolecular_function
GO:0032201Telomere maintenance via semi-conservative replicationTASbiological_process
GO:0032508DNA duplex unwindingIDAbiological_process
GO:0033567DNA replication, Okazaki fragment processingIDA IEAbiological_process
GO:0042645Mitochondrial nucleoidIDAcellular_component
GO:0043137DNA replication, removal of RNA primerIDAbiological_process
GO:00431395'-3' DNA helicase activityIDAmolecular_function
GO:0043142Single-stranded DNA-dependent ATPase activityIDA IEAmolecular_function
GO:0043504Mitochondrial DNA repairIDAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91481450930.00322460010.99999024730.1142324361

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0732776611
GSE13712_SHEARUp0.6235996544
GSE13712_STATICUp0.5224482856
GSE19018Down-0.2542484875
GSE19899_A1Down-0.2925322100
GSE19899_A2Down-1.8645114127
PubMed_21979375_A1Down-1.1011710041
PubMed_21979375_A2Down-2.4624716628
GSE35957Down-1.4831165599
GSE36640Down-2.4044130768
GSE54402Down-0.0128831609
GSE9593Down-0.7557852273
GSE43922Down-0.6225331074
GSE24585Down-0.1624399690
GSE37065Up0.0372981792
GSE28863_A1Down-0.1656750556
GSE28863_A2Up0.2542800541
GSE28863_A3Down-0.6329741594
GSE28863_A4Up0.2745861655
GSE48662Down-0.0683407964

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23950734In the budding yeast model, three proteins - Dpb11(TopBP1), Ddc1(Rad9) and Dna2 - all interact with and activate Mec1(ATR)
23950734Any of the Dpb11(TopBP1), Ddc1(Rad9) or Dna2 ADDs is sufficient to activate Mec1(ATR) in vitro
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