HCSGD entry for DMP1
1. General information
| Official gene symbol | DMP1 |
|---|---|
| Entrez ID | 1758 |
| Gene full name | dentin matrix acidic phosphoprotein 1 |
| Other gene symbols | ARHP ARHR DMP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0005178 | Integrin binding | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | TAS | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0010811 | Positive regulation of cell-substrate adhesion | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0031214 | Biomineral tissue development | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0050840 | Extracellular matrix binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5948422780 | 0.8824941454 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1343896972 |
| GSE13712_SHEAR | Down | -0.2029920834 |
| GSE13712_STATIC | Up | 0.0981862946 |
| GSE19018 | Up | 0.1096616237 |
| GSE19899_A1 | Up | 0.0654247460 |
| GSE19899_A2 | Down | -0.0051136735 |
| PubMed_21979375_A1 | Up | 0.2536627339 |
| PubMed_21979375_A2 | Up | 0.1809622587 |
| GSE35957 | Up | 0.0816220382 |
| GSE36640 | Up | 0.0174206476 |
| GSE54402 | Up | 0.0301022871 |
| GSE9593 | Up | 0.0320113251 |
| GSE43922 | Up | 0.0766287792 |
| GSE24585 | Up | 0.1121938637 |
| GSE37065 | Down | -0.0925590617 |
| GSE28863_A1 | Down | -0.1295312901 |
| GSE28863_A2 | Down | -0.0511307986 |
| GSE28863_A3 | Up | 0.0692406264 |
| GSE28863_A4 | Up | 0.1116247629 |
| GSE48662 | Down | -0.0465296163 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22067611 | RESULTS: With the exogenous expression of hTERT, tDPSCs maintained a continued expression of odontogenic markers for cell proliferation and mineralization (ALP, COL-1, DMP-1, DSPP, OCN amd OPN)as did nDPScs |
| 22067611 | Also examined were the expression of genes involved in proliferation and mineralization such as human alkaline phosphatase (ALP), beta-actin, collagen 1 (col-1), core binding factor (cbfa-1), dentin matrix protein (DMP-1), dentin sialophosphoprotein (DSPP), GAPDH, hTERT, osteocalcin (OCN), osteopontin (OPN) as well as oncoproteins involved in senescence (p16, p21 and p53) using RT-PCR |
| 16630306 | Cell morphology and proliferation were analyzed, and expression of cell-specific gene transcripts and proteins (including collagen types I and III, alkaline phosphatase, bone sialoprotein, osteocalcin, and dentin sialophosphoprotein and dentin matrix protein I) was detected by RT-PCR and immunohistochemistry |
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