HCSGD entry for DLX5

1. General information

Official gene symbolDLX5
Entrez ID1749
Gene full namedistal-less homeobox 5
Other gene symbolsSHFM1D
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinISScellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISSmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001501Skeletal system developmentTASbiological_process
GO:0001649Osteoblast differentiationISSbiological_process
GO:0001958Endochondral ossificationISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030509BMP signaling pathwayISSbiological_process
GO:0030855Epithelial cell differentiationIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060166Olfactory pit developmentIEAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0071773Cellular response to BMP stimulusISSbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:1901522Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79093264310.15540855970.99999024730.7621022520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0071362655
GSE13712_SHEARDown-0.1127800566
GSE13712_STATICUp0.0980303396
GSE19018Down-0.1169904335
GSE19899_A1Down-0.0352672091
GSE19899_A2Down-0.0173380946
PubMed_21979375_A1Up0.2338145545
PubMed_21979375_A2Down-0.0331863055
GSE35957Down-1.1086705288
GSE36640Up0.0647255132
GSE54402Down-0.0146844836
GSE9593Down-0.3392352860
GSE43922Up0.0219377356
GSE24585Up0.6618346875
GSE37065Down-0.4718624868
GSE28863_A1Down-0.1109468887
GSE28863_A2Down-0.2013268516
GSE28863_A3Up0.1072813041
GSE28863_A4Down-0.2503681307
GSE48662Up0.2216979137

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200a-3pMIMAT0000682MIRT000204Luciferase reporter assayFunctional MTI19454767
hsa-miR-141-3pMIMAT0000432MIRT000320Luciferase reporter assayFunctional MTI19454767
hsa-miR-335-5pMIMAT0000765MIRT018111MicroarrayFunctional MTI (Weak)18185580
hsa-miR-423-5pMIMAT0004748MIRT038077CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.