HCSGD entry for DLST
1. General information
| Official gene symbol | DLST |
|---|---|
| Entrez ID | 1743 |
| Gene full name | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) |
| Other gene symbols | DLTS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004149 | Dihydrolipoyllysine-residue succinyltransferase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006091 | Generation of precursor metabolites and energy | TAS | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006554 | Lysine catabolic process | TAS | biological_process |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0016746 | Transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0033512 | L-lysine catabolic process to acetyl-CoA via saccharopine | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045252 | Oxoglutarate dehydrogenase complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6899549979 | 0.8692033205 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Up | 0.3297450342 |
| GSE24585 | Up | 0.3185117620 |
| GSE37065 | Down | -0.0242974958 |
| GSE28863_A1 | Down | -0.1445034148 |
| GSE28863_A2 | Down | -0.1383276685 |
| GSE28863_A3 | Down | -0.1476212423 |
| GSE28863_A4 | Up | 0.0008837218 |
| GSE48662 | Up | 0.2157670095 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036029 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-5p | MIMAT0004792 | MIRT037800 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039832 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040701 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041111 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042860 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045733 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048341 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
