HCSGD entry for DLG4

1. General information

Official gene symbolDLG4
Entrez ID1742
Gene full namediscs, large homolog 4 (Drosophila)
Other gene symbolsPSD95 SAP-90 SAP90
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001973Adenosine receptor signaling pathwayISSbiological_process
GO:0002091Negative regulation of receptor internalizationIEA ISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005886Plasma membraneISS TAScellular_component
GO:0006461Protein complex assemblyIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEA ISSbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007612LearningTASbiological_process
GO:0008021Synaptic vesicleIEA ISScellular_component
GO:0008022Protein C-terminus bindingIEA IPImolecular_function
GO:0008328Ionotropic glutamate receptor complexISScellular_component
GO:0014069Postsynaptic densityISScellular_component
GO:0016188Synaptic vesicle maturationIEA ISSbiological_process
GO:0019903Protein phosphatase bindingIEA ISSmolecular_function
GO:0030054Cell junctionIEA ISScellular_component
GO:0030165PDZ domain bindingIEA ISSmolecular_function
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030863Cortical cytoskeletonIDAcellular_component
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIEA ISScellular_component
GO:0031697Beta-1 adrenergic receptor bindingIEA ISSmolecular_function
GO:0031748D1 dopamine receptor bindingIEA ISSmolecular_function
GO:0031812P2Y1 nucleotide receptor bindingIEA ISSmolecular_function
GO:0032281Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complexIEA ISScellular_component
GO:0032403Protein complex bindingIEA ISSmolecular_function
GO:0032839Dendrite cytoplasmIEA ISScellular_component
GO:0033130Acetylcholine receptor bindingIEA ISSmolecular_function
GO:0035176Social behaviorIEAbiological_process
GO:0035255Ionotropic glutamate receptor bindingIEA ISSmolecular_function
GO:0035418Protein localization to synapseIDAbiological_process
GO:0035641Locomotory exploration behaviorIEAbiological_process
GO:0044224Juxtaparanode region of axonIEA ISScellular_component
GO:0044306Neuron projection terminusIEA ISScellular_component
GO:0044309Neuron spineISScellular_component
GO:0045031ATP-activated nucleotide receptor activityISSmolecular_function
GO:0045032ADP-activated nucleotide receptor activityISSmolecular_function
GO:0045184Establishment of protein localizationIDAbiological_process
GO:0045202SynapseIDAcellular_component
GO:0045211Postsynaptic membraneIDA IEAcellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048169Regulation of long-term neuronal synaptic plasticityIEA ISSbiological_process
GO:0050806Positive regulation of synaptic transmissionIEA ISSbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0060076Excitatory synapseIEA ISScellular_component
GO:0060997Dendritic spine morphogenesisIEA ISSbiological_process
GO:0071625Vocalization behaviorIEAbiological_process
GO:0097110Scaffold protein bindingIEA ISSmolecular_function
GO:0097113Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringIEA ISS TASbiological_process
GO:0097120Receptor localization to synapseIEA ISSbiological_process
GO:0097481Neuronal postsynaptic densityIEA ISScellular_component
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityIEA ISSbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialIEA ISSbiological_process
GO:2000821Regulation of grooming behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15870344590.63303656020.78994580181.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0328700788
GSE13712_SHEARDown-0.5091100296
GSE13712_STATICDown-0.2095825161
GSE19018Up0.0374040493
GSE19899_A1Up0.0833925894
GSE19899_A2Up0.7040258991
PubMed_21979375_A1Up0.4775244849
PubMed_21979375_A2Up0.0127750285
GSE35957Up0.0172441933
GSE36640Up0.7011363640
GSE54402Up0.8724083249
GSE9593Up0.0447569845
GSE43922Up0.3246558225
GSE24585Up0.3219183772
GSE37065Up0.0124829420
GSE28863_A1Down-0.1005321264
GSE28863_A2Down-0.3669589315
GSE28863_A3Up0.1059009428
GSE28863_A4Down-0.0488362217
GSE48662Down-0.6758194626

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GuanidineDB00536 APRD01008 | EXPT01546
Guanosine-5'-MonophosphateDB01972 EXPT00246

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019881qRT-PCR;MicroarrayFunctional MTI (Weak)20584986
hsa-miR-10a-5pMIMAT0000253MIRT047670CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.