HCSGD entry for DLAT

1. General information

Official gene symbolDLAT
Entrez ID1737
Gene full namedihydrolipoamide S-acetyltransferase
Other gene symbolsDLTA PDC-E2 PDCE2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004742Dihydrolipoyllysine-residue acetyltransferase activityIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005759Mitochondrial matrixTAScellular_component
GO:0005967Mitochondrial pyruvate dehydrogenase complexNAScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006090Pyruvate metabolic processIEA TASbiological_process
GO:0006099Tricarboxylic acid cycleIEAbiological_process
GO:0010510Regulation of acetyl-CoA biosynthetic process from pyruvateTASbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045254Pyruvate dehydrogenase complexIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62621700540.28968039970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0889718330
GSE13712_SHEARUp0.1560344339
GSE13712_STATICUp0.1109985714
GSE19018Down-0.3687556524
GSE19899_A1Up0.1106375160
GSE19899_A2Up0.1676900443
PubMed_21979375_A1Up0.3745380488
PubMed_21979375_A2Down-0.0337298628
GSE35957Down-0.2145368989
GSE36640Down-0.1355278270
GSE54402Up0.3037785660
GSE9593Down-0.4202960076
GSE43922Up0.1964042660
GSE24585Down-0.3754670483
GSE37065Down-0.0197393488
GSE28863_A1Down-0.1753782535
GSE28863_A2Up0.1795603517
GSE28863_A3Down-0.5943146574
GSE28863_A4Up0.1703058563
GSE48662Down-0.3759374832

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
RadicicolDB03758 EXPT02763
Dihydrolipoic AcidDB03760 EXPT02769

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032242ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT040451CLASHFunctional MTI (Weak)23622248
hsa-miR-10b-5pMIMAT0000254MIRT047485CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26201620Biliary specificity in PBC is most likely driven by the uniqueness of cholangiocyte apoptosis in which the PDC-E2 autoantigen undergoes differential glutathiolation
23231002METHODS: We examined immunohistochemically the expression of pyruvate dehydrogenase complex-E2 component (PDC-E2) and cytochrome c oxidase, subunit I (CCO), in livers taken from patients with PBC (n = 42) and control livers (n = 76)
23231002RESULTS: Intense granular expression of PDC-E2 and CCO was seen in the damaged small bile ducts (SBDs) in PBC and the expression was significantly more frequent in PBC than in control livers (P < 0
23231002The accumulation of LC3-expressing punctae colocalized with PDC-E2 and CCO was significantly more increased in cultured BECs treated with various stresses
23231002The cell-surface expression of PDC-E2 was induced by various stresses in BECs
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