HCSGD entry for DIAPH1
1. General information
| Official gene symbol | DIAPH1 |
|---|---|
| Entrez ID | 1729 |
| Gene full name | diaphanous-related formin 1 |
| Other gene symbols | DFNA1 DIA1 DRF1 LFHL1 hDIA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005102 | Receptor binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005522 | Profilin binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007010 | Cytoskeleton organization | IMP | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0008360 | Regulation of cell shape | IMP | biological_process |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0030041 | Actin filament polymerization | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IEA | biological_process |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0032886 | Regulation of microtubule-based process | IMP | biological_process |
| GO:0035372 | Protein localization to microtubule | IMP | biological_process |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0044325 | Ion channel binding | IEA IPI | molecular_function |
| GO:0051279 | Regulation of release of sequestered calcium ion into cytosol | IMP | biological_process |
| GO:0071420 | Cellular response to histamine | IMP | biological_process |
| GO:0072686 | Mitotic spindle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0780580411 | 0.6935472702 | 0.5893518497 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1242915011 |
| GSE13712_SHEAR | Up | 0.1647993423 |
| GSE13712_STATIC | Down | -0.1330270282 |
| GSE19018 | Down | -0.2147575958 |
| GSE19899_A1 | Up | 0.2036196982 |
| GSE19899_A2 | Up | 0.1539123246 |
| PubMed_21979375_A1 | Up | 0.4215888183 |
| PubMed_21979375_A2 | Up | 0.7238492660 |
| GSE35957 | Up | 0.1934291911 |
| GSE36640 | Down | -0.6946384426 |
| GSE54402 | Up | 0.1882006702 |
| GSE9593 | Down | -0.1692601018 |
| GSE43922 | Up | 0.5715937611 |
| GSE24585 | Down | -0.0322524734 |
| GSE37065 | Up | 0.1471225078 |
| GSE28863_A1 | Up | 0.2332654770 |
| GSE28863_A2 | Up | 0.7877486499 |
| GSE28863_A3 | Down | -0.3971586403 |
| GSE28863_A4 | Down | -0.2421866230 |
| GSE48662 | Down | -0.0789686745 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032344 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032344 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039957 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043807 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044627 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045342 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046188 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046300 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049688 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050684 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051524 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
