HCSGD entry for NQO1
1. General information
| Official gene symbol | NQO1 |
|---|---|
| Entrez ID | 1728 |
| Gene full name | NAD(P)H dehydrogenase, quinone 1 |
| Other gene symbols | DHQU DIA4 DTD NMOR1 NMORI QR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | IEA | molecular_function |
| GO:0004128 | Cytochrome-b5 reductase activity, acting on NAD(P)H | TAS | molecular_function |
| GO:0004784 | Superoxide dismutase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006521 | Regulation of cellular amino acid metabolic process | TAS | biological_process |
| GO:0006801 | Superoxide metabolic process | IEA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0006809 | Nitric oxide biosynthetic process | TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0007271 | Synaptic transmission, cholinergic | TAS | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0009636 | Response to toxic substance | TAS | biological_process |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043086 | Negative regulation of catalytic activity | IEA | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0707528893 | 0.0026796512 | 0.5682901434 | 0.1026653566 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4949009600 |
| GSE13712_SHEAR | Up | 0.4670151777 |
| GSE13712_STATIC | Up | 0.9544993246 |
| GSE19018 | Down | -1.2553232092 |
| GSE19899_A1 | Down | -2.2037771303 |
| GSE19899_A2 | Down | -1.0121371759 |
| PubMed_21979375_A1 | Down | -1.2612209464 |
| PubMed_21979375_A2 | Down | -1.7533927729 |
| GSE35957 | Down | -0.9866199907 |
| GSE36640 | Up | 0.8044694047 |
| GSE54402 | Up | 0.1396481553 |
| GSE9593 | Up | 0.2225438975 |
| GSE43922 | Down | -0.4292947194 |
| GSE24585 | Up | 1.7600092656 |
| GSE37065 | Down | -0.0693571715 |
| GSE28863_A1 | Down | -0.0992618767 |
| GSE28863_A2 | Down | -1.0447469023 |
| GSE28863_A3 | Down | -1.0744496847 |
| GSE28863_A4 | Up | 0.5167435941 |
| GSE48662 | Down | -0.4605410590 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Menadione | DB00170 | NUTR00062 |
| Duroquinone | DB01927 | EXPT01265 |
| 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol | DB02395 | EXPT01312 |
| 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione | DB02400 | EXPT00341 |
| Cibacron Blue | DB02633 | EXPT00841 |
| 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione | DB03626 | EXPT00154 |
| 2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione | DB04090 | EXPT02778 |
| Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] | DB04392 | EXPT01281 |
| 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE | DB07385 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26078718 | NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence |
| 26078718 | In this study, we report that expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a cytoplasmic 2-electron reductase, is induced during oncogene-induced senescence (OIS) |
| 26078718 | Depletion of NQO1 resulted in the delayed onset of senescence |
| 26078718 | In contrast, ectopic expression of NQO1 enhanced the senescence phenotype |
| 26078718 | Analysis of the mechanism underlying the up-regulation of NQO1 expression during senescence identified that NQO1 promotes p53 accumulation in an MDM2 and ubiquitin independent manner, which reinforces the cellular senescence phenotype |
| 26078718 | More importantly, we confirmed that depletion of NQO1 facilitates cell transformation and tumorigenesis, which indicates that NQO1 takes part in the senescence barrier and has anti-oncogenic properties in cell transformation |
| 20448207 | Expression analysis revealed that GLP-1 can induce the oxidative defense genes HO-1 and NQO1 |
| 19362588 | Polyphenol cytotoxicity induced by the bacterial toxin pyocyanin: role of NQO1 |
| 19362588 | On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1) |
| 19362588 | Pyocyanin inhibited cellular NQO1 activity at low micromolar concentrations, but the presence of exogenous ascorbate eliminated pyocyanin-induced polyphenol cytotoxicity |
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