HCSGD entry for DHODH

1. General information

Official gene symbolDHODH
Entrez ID1723
Gene full namedihydroorotate dehydrogenase (quinone)
Other gene symbolsDHOdehase POADS URA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004152Dihydroorotate dehydrogenase activityIEA TASmolecular_function
GO:0004158Dihydroorotate oxidase activityIEAmolecular_function
GO:0005743Mitochondrial inner membraneIEA TAScellular_component
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0006207'de novo' pyrimidine nucleobase biosynthetic processIEAbiological_process
GO:0006222UMP biosynthetic processIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0010181FMN bindingIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0031000Response to caffeineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0044205'de novo' UMP biosynthetic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046134Pyrimidine nucleoside biosynthetic processTASbiological_process
GO:0048039Ubiquinone bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0090140Regulation of mitochondrial fissionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94043509370.07883676150.99999024730.5313689964

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0646255875
GSE13712_SHEARDown-0.1254495940
GSE13712_STATICUp0.1020337801
GSE19018Down-0.3437535929
GSE19899_A1Down-0.0008918269
GSE19899_A2Down-0.1646887005
PubMed_21979375_A1Down-0.0696629654
PubMed_21979375_A2Down-0.3785849996
GSE35957Down-0.1420910546
GSE36640Down-0.2455632793
GSE54402Down-0.0974911058
GSE9593Down-0.5312744294
GSE43922Down-0.0003314295
GSE24585Down-0.5503434086
GSE37065Down-0.2510347654
GSE28863_A1Down-0.0129815817
GSE28863_A2Up0.1441781593
GSE28863_A3Up0.3701090530
GSE28863_A4Up0.2358075670
GSE48662Down-0.3510080917

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AtovaquoneDB01117 APRD00805
Orotic AcidDB02262 EXPT02447
Decylamine-N,N-Dimethyl-N-OxideDB02613 EXPT01149
Riboflavin MonophosphateDB03247 EXPT01458
Brequinar AnalogDB03480 EXPT00751
6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic AcidDB03523 EXPT00752
Antiproliferative Agent A771726DB03805 EXPT00364
Lauryl Dimethylamine-N-OxideDB04147 EXPT02013
2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-NaphthalenoneDB04281 EXPT00451
5-(AMINOCARBONYL)-1,1':4',1''-TERPHENYL-3-CARBOXYLICACIDDB04583 -
SC12267DB05125 -
(2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamideDB07443 -
(2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamideDB07559 -
(2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamideDB07561 -
UNDECYLAMINE-N,N-DIMETHYL-N-OXIDEDB07646 -
2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACIDDB07975 -
3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACIDDB07976 -
3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACIDDB07977 -
2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACIDDB07978 -
N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amineDB08006 -
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amineDB08008 -
(2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamideDB08169 -
(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamideDB08172 -
3,6,9,12,15-PENTAOXATRICOSAN-1-OLDB08249 -
TeriflunomideDB08880 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029671MicroarrayFunctional MTI (Weak)19088304
hsa-miR-615-3pMIMAT0003283MIRT039774CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.