HCSGD entry for DDX53
1. General information
| Official gene symbol | DDX53 |
|---|---|
| Entrez ID | 168400 |
| Gene full name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 |
| Other gene symbols | CAGE CT26 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2771762509 | 0.9238296189 | 0.9740395327 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1063616267 |
| GSE13712_SHEAR | Up | 0.1629055752 |
| GSE13712_STATIC | Down | -0.0427607215 |
| GSE19018 | Up | 0.2561477730 |
| GSE19899_A1 | Up | 0.1167033501 |
| GSE19899_A2 | Up | 0.0640762079 |
| PubMed_21979375_A1 | Up | 0.2251231212 |
| PubMed_21979375_A2 | Down | -0.2432168858 |
| GSE35957 | Down | -0.0504601424 |
| GSE36640 | Up | 0.2410301720 |
| GSE54402 | Up | 0.1148973877 |
| GSE9593 | Up | 0.1774776074 |
| GSE43922 | Up | 0.0135543425 |
| GSE24585 | Up | 0.2945941316 |
| GSE37065 | Down | -0.0780807355 |
| GSE28863_A1 | Up | 0.0908970770 |
| GSE28863_A2 | Up | 0.1266309741 |
| GSE28863_A3 | Up | 0.1541822981 |
| GSE28863_A4 | Down | -0.0223738486 |
| GSE48662 | Up | 0.0355197369 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23758730 | Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma |
| 23758730 | In present study, we evaluated the anticancer potential of TLBZT, used alone or in combination with low dose of 5-Fluorouracil (5-Fu), in CT26 colon carcinoma in vivo |
| 23758730 | METHODS: CT26 colon carcinoma was established in BALB/c mice and treated with TLBZT, 5-Fu, or TLBZT plus 5-Fu |
| 23758730 | RESULTS: TLBZT significantly inhibited CT26 colon carcinoma growth |
| 23758730 | TLBZT also induced cell senescence in CT26 colon carcinoma, with concomitant upregulation of p16 and p21 and downregulation of RB phosphorylation |
| 23758730 | In addition, angiogenesis and VEGF expression in CT26 colon carcinoma was significantly inhibited by TLBZT treatment |
| 23758730 | Furthermore, TLBZT significantly enhanced anticancer effects of 5-Fu in CT26 colon carcinoma |
| 23758730 | CONCLUSIONS: TLBZT exhibited significantly anticancer effect, and enhanced the effects of 5-Fu in CT26 colon carcinoma, which may correlate with induction of apoptosis and cell senescence, and angiogenesis inhibition |
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