HCSGD entry for DDX3X

1. General information

Official gene symbolDDX3X
Entrez ID1654
Gene full nameDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Other gene symbolsDBX DDX14 DDX3 HLP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIDAmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIDAmolecular_function
GO:0004004ATP-dependent RNA helicase activityIDAmolecular_function
GO:0004386Helicase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005852Eukaryotic translation initiation factor 3 complexIDAcellular_component
GO:0006200ATP catabolic processIDA TASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007059Chromosome segregationIMPbiological_process
GO:0008134Transcription factor bindingIDAmolecular_function
GO:0008143Poly(A) bindingIDAmolecular_function
GO:0008190Eukaryotic initiation factor 4E bindingIDAmolecular_function
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:0009615Response to virusIDAbiological_process
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0010501RNA secondary structure unwindingIDAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0016887ATPase activityIDAmolecular_function
GO:0017148Negative regulation of translationIMPbiological_process
GO:0022627Cytosolic small ribosomal subunitIDAcellular_component
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0031333Negative regulation of protein complex assemblyIDAbiological_process
GO:0031369Translation initiation factor bindingIDAmolecular_function
GO:0032508DNA duplex unwindingIDAbiological_process
GO:0032728Positive regulation of interferon-beta productionTASbiological_process
GO:0034063Stress granule assemblyIDAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0035613RNA stem-loop bindingIDAmolecular_function
GO:0042256Mature ribosome assemblyIMPbiological_process
GO:0043024Ribosomal small subunit bindingIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0045087Innate immune responseIMPbiological_process
GO:0045727Positive regulation of translationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0045948Positive regulation of translational initiationIMPbiological_process
GO:0048027MRNA 5'-UTR bindingIDAmolecular_function
GO:0071243Cellular response to arsenic-containing substanceIDAbiological_process
GO:0071470Cellular response to osmotic stressIDAbiological_process
GO:0071651Positive regulation of chemokine (C-C motif) ligand 5 productionTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIMPbiological_process
GO:1900087Positive regulation of G1/S transition of mitotic cell cycleIMPbiological_process
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34774943580.85629249650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0254300257
GSE13712_SHEARDown-0.0229051378
GSE13712_STATICDown-0.1132539897
GSE19018Down-0.2695162924
GSE19899_A1Up0.1552946649
GSE19899_A2Up0.1311802773
PubMed_21979375_A1Up0.0440184840
PubMed_21979375_A2Up0.5625327219
GSE35957Up0.3083785670
GSE36640Up0.2053343520
GSE54402Up0.0928393180
GSE9593Up0.1071523703
GSE43922Up0.1884887458
GSE24585Up0.0719488796
GSE37065Up0.1302662002
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.7686190945

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004132MicroarrayFunctional MTI (Weak)16822819
hsa-miR-192-5pMIMAT0000222MIRT004132MicroarrayFunctional MTI (Weak)19074876
hsa-miR-421MIMAT0003339MIRT016125SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022863Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024813MicroarrayFunctional MTI (Weak)19074876
hsa-miR-181a-5pMIMAT0000256MIRT025200SequencingFunctional MTI (Weak)20371350
hsa-miR-181a-5pMIMAT0000256MIRT025200CLASHFunctional MTI (Weak)23622248
hsa-miR-26b-5pMIMAT0000083MIRT029833SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT030902MicroarrayFunctional MTI (Weak)18591254
hsa-miR-16-5pMIMAT0000069MIRT031843ProteomicsFunctional MTI (Weak)18668040
hsa-miR-505-5pMIMAT0004776MIRT037942CLASHFunctional MTI (Weak)23622248
hsa-miR-130b-5pMIMAT0004680MIRT038287CLASHFunctional MTI (Weak)23622248
hsa-miR-629-3pMIMAT0003298MIRT039582CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040544CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048615CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.