HCSGD entry for GADD45A
1. General information
| Official gene symbol | GADD45A |
|---|---|
| Entrez ID | 1647 |
| Gene full name | growth arrest and DNA-damage-inducible, alpha |
| Other gene symbols | DDIT1 GADD45 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000185 | Activation of MAPKKK activity | IDA | biological_process |
| GO:0001047 | Core promoter binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | IEA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0007098 | Centrosome cycle | IEA | biological_process |
| GO:0042770 | Signal transduction in response to DNA damage | IMP | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IDA | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
| GO:0071479 | Cellular response to ionizing radiation | IMP | biological_process |
| GO:1900745 | Positive regulation of p38MAPK cascade | IDA | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2120438433 | 0.1214434368 | 0.8878723573 | 0.6698475901 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2465055955 |
| GSE13712_SHEAR | Down | -0.2473478411 |
| GSE13712_STATIC | Up | 0.0833638876 |
| GSE19018 | Down | -0.3501770752 |
| GSE19899_A1 | Down | -0.2772247373 |
| GSE19899_A2 | Up | 0.0977761849 |
| PubMed_21979375_A1 | Down | -0.1016459176 |
| PubMed_21979375_A2 | Down | -0.1488271435 |
| GSE35957 | Up | 0.6489041570 |
| GSE36640 | Up | 0.7278378897 |
| GSE54402 | Down | -0.5822916694 |
| GSE9593 | Up | 0.8903335420 |
| GSE43922 | Down | -0.2259014810 |
| GSE24585 | Up | 0.5891614988 |
| GSE37065 | Up | 0.0493174385 |
| GSE28863_A1 | Down | -0.2842164756 |
| GSE28863_A2 | Up | 0.1250581837 |
| GSE28863_A3 | Down | -0.0990583271 |
| GSE28863_A4 | Down | -0.0780093368 |
| GSE48662 | Down | -0.3630920614 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-374a-5p | MIMAT0000727 | MIRT005574 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21274007 |
| hsa-miR-504-5p | MIMAT0002875 | MIRT016251 | qRT-PCR | Functional MTI (Weak) | 20542001 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029880 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039859 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24872428 | GADD45 proteins: roles in cellular senescence and tumor development |
| 24872428 | Recent studies have provided important insights regarding how different oncogenic stresses activate GADD45 signaling pathway and lead to disparate influences on tumor initiation |
| 24872428 | In this review, we discuss the deregulation and cellular function of GADD45 proteins in the context of cancer development |
| 24804545 | Mechanically, PRIMA-1 induced global DNA demethylation in these cells mainly through inhibiting the expression of DNA methyltransferase (DNMT) 1, 3a and 3b, and upregulating the expression of GADD45a |
| 24721210 | These data suggest that the expression of Gadd45alpha is involved in maintaining the balance of pro- and anti-apoptotic stimuli, while lack or loss of Gadd45 directs the cells to apoptosis after HDIs treatment |
| 23514618 | Gene array qPCR analysis of MIA PaCa-2 cells treated with the lead compound revealed significant dose-dependent modulation of a distinct subset of genes, including strong induction of DNA damage responsive genes CDKN1A, DDIT3, GADD45A/G, and PPM1D, and repression of genes involved in telomere maintenance, including hPOT1 and PARP1 |
| 21986581 | Gadd45 proteins: relevance to aging, longevity and age-related pathologies |
| 21986581 | The Gadd45 proteins have been intensively studied, in view of their important role in key cellular processes |
| 21986581 | Indeed, the Gadd45 proteins stand at the crossroad of the cell fates by controlling the balance between cell (DNA) repair, eliminating (apoptosis) or preventing the expansion of potentially dangerous cells (cell cycle arrest, cellular senescence), and maintaining the stem cell pool |
| 21986581 | Here we analyzed the pathways and modes of action by which Gadd45 members are involved in aging, longevity and age-related diseases |
| 21986581 | Because of their pleiotropic action, a decreased inducibility of Gadd45 members may have far-reaching consequences including genome instability, accumulation of DNA damage, and disorders in cellular homeostasis - all of which may eventually contribute to the aging process and age-related disorders (promotion of tumorigenesis, immune disorders, insulin resistance and reduced responsiveness to stress) |
| 16951143 | In this study, we used chromatin immunoprecipitation to determine that p53 preferentially occupied the promoters of growth arrest genes p21 and GADD45 in senescent normal human diploid fibroblasts but not the promoters of other target genes that recruited p53 following doxorubicin-induced DNA damage, such as apoptosis regulators TNFRSF10b, TNFRSF6, and PUMA |
| 15736438 | Checkpoint effectors CDKN1A and Gadd45 correlate with oxidative DNA damage in human prostate carcinoma |
| 15736438 | MATERIALS AND METHODS: We examined the expression of CDKN1A and Gadd45 proteins acting on cell cycle checkpoints and DNA repair in PCa relative to the presence of oxidative DNA damage, as measured by the detection of the DNA adduct 8-hydroxy-2-deoxyguanosine (8-OHdG |
| 15736438 | RT-PCR was used to evaluate WAF1 and Gadd45 transcripts |
Entries Per Page
Displaying Page of
