HCSGD entry for DCTN1
1. General information
| Official gene symbol | DCTN1 |
|---|---|
| Entrez ID | 1639 |
| Gene full name | dynactin 1 |
| Other gene symbols | DAP-150 DP-150 P135 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0003774 | Motor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005869 | Dynactin complex | IEA | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007067 | Mitosis | NAS | biological_process |
| GO:0007399 | Nervous system development | NAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0010970 | Microtubule-based transport | IEA | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030286 | Dynein complex | IEA | cellular_component |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0031252 | Cell leading edge | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045502 | Dynein binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0054529501 | 0.9913991946 | 0.1942179973 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1200124761 |
| GSE13712_SHEAR | Down | -0.6137678982 |
| GSE13712_STATIC | Down | -0.0824421375 |
| GSE19018 | Up | 0.3559004315 |
| GSE19899_A1 | Down | -0.0493446494 |
| GSE19899_A2 | Up | 0.5818532295 |
| PubMed_21979375_A1 | Up | 0.2626441728 |
| PubMed_21979375_A2 | Up | 2.0015854792 |
| GSE35957 | Up | 0.8704897204 |
| GSE36640 | Up | 0.8075873060 |
| GSE54402 | Up | 0.2701930028 |
| GSE9593 | Up | 0.4473139492 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.3903972007 |
| GSE28863_A2 | Up | 0.8359058717 |
| GSE28863_A3 | Up | 0.3346072845 |
| GSE28863_A4 | Down | -0.0708822083 |
| GSE48662 | Up | 0.3620187156 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036100 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044073 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048854 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050276 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
