HCSGD entry for DCT
1. General information
| Official gene symbol | DCT |
|---|---|
| Entrez ID | 1638 |
| Gene full name | dopachrome tautomerase |
| Other gene symbols | TRP-2 TYRP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002052 | Positive regulation of neuroblast proliferation | IEA | biological_process |
| GO:0004167 | Dopachrome isomerase activity | ISS | molecular_function |
| GO:0005507 | Copper ion binding | TAS | molecular_function |
| GO:0005829 | Cytosol | ISS | cellular_component |
| GO:0006583 | Melanin biosynthetic process from tyrosine | ISS | biological_process |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0021847 | Ventricular zone neuroblast division | IEA | biological_process |
| GO:0033162 | Melanosome membrane | IEA | cellular_component |
| GO:0042470 | Melanosome | ISS | cellular_component |
| GO:0048066 | Developmental pigmentation | IEA | biological_process |
| GO:0048468 | Cell development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4448161392 | 0.9451892785 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0828513449 |
| GSE13712_SHEAR | Down | -0.0494548855 |
| GSE13712_STATIC | Up | 0.0115840638 |
| GSE19018 | Up | 0.2882634429 |
| GSE19899_A1 | Up | 0.1470783302 |
| GSE19899_A2 | Up | 0.0757565302 |
| PubMed_21979375_A1 | Down | -0.0036082477 |
| PubMed_21979375_A2 | Down | -0.0777739319 |
| GSE35957 | Up | 0.0581144679 |
| GSE36640 | Up | 0.0882884787 |
| GSE54402 | Up | 0.0982932370 |
| GSE9593 | Up | 0.0612597401 |
| GSE43922 | Up | 0.0138388637 |
| GSE24585 | Up | 0.0950602728 |
| GSE37065 | Up | 0.0278457071 |
| GSE28863_A1 | Down | -0.0930004627 |
| GSE28863_A2 | Down | -0.0250306589 |
| GSE28863_A3 | Up | 0.1780761664 |
| GSE28863_A4 | Up | 0.0290445171 |
| GSE48662 | Up | 0.3186498970 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15892717 | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes |
| 15892717 | Since virtually nothing is known regarding the differentiated function of senescent melanocytes, we analyzed the transcriptional regulation of Dopachrome tautomerase (DCT), a member of the tyrosinase gene family, in proliferating and in senescent human melanocytes |
| 15892717 | Importantly, a promoter-reporter analysis demonstrated that the coactivator p300/CBP switched MITF from a repressor to an activator of DCT transcription |
| 15892717 | We have also found that transcription of the DCT gene is differentially regulated by major melanocyte mitogens |
| 15892717 | In support of this conclusion, trichostatin A, a histone deacetylase inhibitor, counteracted the TPA-mediated repression, and restored high levels of DCT protein in cultured melanocytes |
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