HCSGD entry for AP2B1
1. General information
| Official gene symbol | AP2B1 |
|---|---|
| Entrez ID | 163 |
| Gene full name | adaptor-related protein complex 2, beta 1 subunit |
| Other gene symbols | ADTB2 AP105B AP2-BETA CLAPB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005802 | Trans-Golgi network | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005905 | Coated pit | IEA | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0006897 | Endocytosis | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016192 | Vesicle-mediated transport | IEA | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030117 | Membrane coat | IEA | cellular_component |
| GO:0030118 | Clathrin coat | IEA | cellular_component |
| GO:0030131 | Clathrin adaptor complex | IEA | cellular_component |
| GO:0030276 | Clathrin binding | IEA IPI | molecular_function |
| GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
| GO:0030669 | Clathrin-coated endocytic vesicle membrane | TAS | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048268 | Clathrin coat assembly | IEA | biological_process |
| GO:0050690 | Regulation of defense response to virus by virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7519669959 | 0.1056258501 | 0.9999902473 | 0.6223414634 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1105141160 |
| GSE13712_SHEAR | Down | -0.1242090080 |
| GSE13712_STATIC | Up | 0.1558952843 |
| GSE19018 | Up | 0.3928856194 |
| GSE19899_A1 | Down | -1.0280282745 |
| GSE19899_A2 | Down | -0.8714326578 |
| PubMed_21979375_A1 | Down | -0.2213922082 |
| PubMed_21979375_A2 | Down | -0.2404028955 |
| GSE35957 | Down | -0.0927228507 |
| GSE36640 | Down | -0.0423493970 |
| GSE54402 | Down | -0.2474853329 |
| GSE9593 | Up | 0.5864676786 |
| GSE43922 | Down | -0.3714917622 |
| GSE24585 | Up | 0.0293744705 |
| GSE37065 | Down | -0.2316781655 |
| GSE28863_A1 | Up | 0.0804169753 |
| GSE28863_A2 | Up | 0.1032669007 |
| GSE28863_A3 | Down | -0.1955714210 |
| GSE28863_A4 | Down | -0.0613481833 |
| GSE48662 | Up | 0.4436387036 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025304 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031985 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037122 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037404 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-532-3p | MIMAT0004780 | MIRT037922 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040259 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044360 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048704 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049362 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT050627 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
