HCSGD entry for DBC1
1. General information
| Official gene symbol | DBC1 |
|---|---|
| Entrez ID | 1620 |
| Gene full name | deleted in bladder cancer 1 |
| Other gene symbols | BRINP1 DBCCR1 FAM5A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0008219 | Cell death | IDA | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0045786 | Negative regulation of cell cycle | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1079087155 | 0.6103499373 | 0.6821991365 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0717845793 |
| GSE13712_SHEAR | Up | 0.0782742283 |
| GSE13712_STATIC | Down | -0.0478427091 |
| GSE19018 | Down | -0.0308964255 |
| GSE19899_A1 | Up | 0.1482171858 |
| GSE19899_A2 | Down | -0.0024767158 |
| PubMed_21979375_A1 | Up | 0.1782641345 |
| PubMed_21979375_A2 | Down | -0.1428058360 |
| GSE35957 | Up | 0.1131677054 |
| GSE36640 | Down | -0.1125564195 |
| GSE54402 | Down | -0.0110295448 |
| GSE9593 | Up | 0.2885725117 |
| GSE43922 | Up | 0.0372481600 |
| GSE24585 | Down | -0.1759214758 |
| GSE37065 | Down | -0.5175495842 |
| GSE28863_A1 | Up | 0.9958530866 |
| GSE28863_A2 | Up | 0.4800741618 |
| GSE28863_A3 | Up | 0.2565466750 |
| GSE28863_A4 | Up | 0.0156225873 |
| GSE48662 | Up | 0.2477905730 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24992635 | Deletion of DBC1 protects preadipocytes against cellular senescence and senescence-driven inflammation |
| 24992635 | Furthermore, we show protection against cellular senescence in DBC1 KO mice during obesity |
| 24992635 | Finally, we found that DBC1 participates in the onset of cellular senescence in response to cell damage by mechanism that involves binding and inhibition of HDAC3 |
| 24992635 | We propose that by regulating HDAC3 activity during cellular damage, DBC1 participates in the fate decision that leads to the establishment of cellular senescence and consequently to inflammation and tissue dysfunction during obesity |
| 22190494 | The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop |
| 22190494 | In various cell lines inactivation of SIRT1 by RNA interference, chemical inhibitors, or ectopic DBC1 enhanced c-MYC-induced apoptosis |
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