HCSGD entry for DAP
1. General information
| Official gene symbol | DAP |
|---|---|
| Entrez ID | 1611 |
| Gene full name | death-associated protein |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0006915 | Apoptotic process | IGI | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0010507 | Negative regulation of autophagy | IMP | biological_process |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IMP | biological_process |
| GO:0034198 | Cellular response to amino acid starvation | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0070513 | Death domain binding | IPI | molecular_function |
| GO:0097190 | Apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0358427111 | 0.8610494510 | 0.4312288848 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3340149418 |
| GSE13712_SHEAR | Down | -0.2844261043 |
| GSE13712_STATIC | Up | 0.2073102449 |
| GSE19018 | Up | 1.1477795572 |
| GSE19899_A1 | Down | -0.1759053947 |
| GSE19899_A2 | Up | 0.3240353692 |
| PubMed_21979375_A1 | Down | -0.1184351655 |
| PubMed_21979375_A2 | Up | 0.2975084528 |
| GSE35957 | Down | -0.0447569212 |
| GSE36640 | Up | 0.7702341582 |
| GSE54402 | Up | 0.3947099695 |
| GSE9593 | Up | 0.1832068370 |
| GSE43922 | Up | 0.0215647404 |
| GSE24585 | Up | 0.0667684485 |
| GSE37065 | Down | -0.1603682420 |
| GSE28863_A1 | Up | 0.1014006093 |
| GSE28863_A2 | Up | 0.2902085349 |
| GSE28863_A3 | Up | 0.0291510210 |
| GSE28863_A4 | Down | -0.2218068033 |
| GSE48662 | Up | 0.2065594194 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-183-5p | MIMAT0000261 | MIRT005726 | qRT-PCR | Non-Functional MTI (Weak) | 20602797 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018510 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17056041 | Death-associated protein 3 regulates cellular senescence through oxidative stress response |
| 17056041 | Death-associated protein 3 (DAP3) has been originally identified as a positive mediator of apoptosis |
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