HCSGD entry for SLC5A8
1. General information
| Official gene symbol | SLC5A8 |
|---|---|
| Entrez ID | 160728 |
| Gene full name | solute carrier family 5 (iodide transporter), member 8 |
| Other gene symbols | AIT SMCT SMCT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006814 | Sodium ion transport | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0015293 | Symporter activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9081330269 | 0.5463886630 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1757406083 |
| GSE13712_SHEAR | Down | -0.1646455075 |
| GSE13712_STATIC | Up | 0.0114512850 |
| GSE19018 | Up | 0.1799095020 |
| GSE19899_A1 | Up | 0.0087754392 |
| GSE19899_A2 | Down | -0.0508796341 |
| PubMed_21979375_A1 | Down | -0.1433406094 |
| PubMed_21979375_A2 | Down | -0.1170999191 |
| GSE35957 | Up | 0.2341409734 |
| GSE36640 | Down | -0.0896689635 |
| GSE54402 | Down | -0.0157920786 |
| GSE9593 | Down | -0.0249242654 |
| GSE43922 | Up | 0.0116742921 |
| GSE24585 | Up | 0.0882006254 |
| GSE37065 | Down | -0.0562131786 |
| GSE28863_A1 | Down | -0.1561379045 |
| GSE28863_A2 | Down | -0.1349984207 |
| GSE28863_A3 | Up | 0.2262126829 |
| GSE28863_A4 | Up | 0.0295594118 |
| GSE48662 | Up | 0.0470305232 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23169885 | The expression of Slc5a8 was decreased in Hfe(-/-) RPE cells, but treatment with a DNA methylation inhibitor restored the transporter expression, indicating involvement of DNA methylation in the silencing of Slc5a8 in Hfe(-/-) cells |
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