HCSGD entry for DGKA
1. General information
| Official gene symbol | DGKA |
|---|---|
| Entrez ID | 1606 |
| Gene full name | diacylglycerol kinase, alpha 80kDa |
| Other gene symbols | DAGK DAGK1 DGK-alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003951 | NAD+ kinase activity | IEA | molecular_function |
| GO:0004143 | Diacylglycerol kinase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005543 | Phospholipid binding | IEA | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA TAS | cellular_component |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0710460013 | 0.0804104479 | 0.5687353406 | 0.5365549417 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3359559596 |
| GSE13712_SHEAR | Up | 0.0345735616 |
| GSE13712_STATIC | Up | 0.1726707068 |
| GSE19018 | Up | 0.2447138448 |
| GSE19899_A1 | Down | -0.3201627426 |
| GSE19899_A2 | Up | 0.1498627477 |
| PubMed_21979375_A1 | Down | -1.8876614794 |
| PubMed_21979375_A2 | Down | -0.5614809141 |
| GSE35957 | Down | -0.4990299878 |
| GSE36640 | Up | 1.2559553730 |
| GSE54402 | Down | -0.6605878785 |
| GSE9593 | Up | 0.3835663301 |
| GSE43922 | Down | -0.6630889150 |
| GSE24585 | Up | 1.4543549735 |
| GSE37065 | Up | 0.1682190428 |
| GSE28863_A1 | Down | -0.2528098436 |
| GSE28863_A2 | Down | -0.1551282548 |
| GSE28863_A3 | Down | -0.5091627300 |
| GSE28863_A4 | Up | 0.2747264142 |
| GSE48662 | Up | 0.3168279106 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin E | DB00163 | NUTR00061 | EXPT03227 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023096 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-484 | MIMAT0002174 | MIRT042155 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
