HCSGD entry for DAB2

1. General information

Official gene symbolDAB2
Entrez ID1601
Gene full nameDab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Other gene symbolsDOC-2 DOC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000904Cell morphogenesis involved in differentiationIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001921Positive regulation of receptor recyclingIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005546Phosphatidylinositol-4,5-bisphosphate bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005765Lysosomal membraneTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005905Coated pitIDAcellular_component
GO:0006907PinocytosisIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007257Activation of JUN kinase activityIEAbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0007588ExcretionIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDA IEAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDA IEAbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030099Myeloid cell differentiationIEAbiological_process
GO:0030132Clathrin coat of coated pitIEAcellular_component
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0030665Clathrin-coated vesicle membraneIEAcellular_component
GO:0032091Negative regulation of protein bindingIMPbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0032968Positive regulation of transcription elongation from RNA polymerase II promoterIEAbiological_process
GO:0035612AP-2 adaptor complex bindingIEAmolecular_function
GO:0035615Clathrin adaptor activityIEA IMPmolecular_function
GO:0038024Cargo receptor activityIEA IMPmolecular_function
GO:0043066Negative regulation of apoptotic processIDA IEAbiological_process
GO:0045807Positive regulation of endocytosisIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0048268Clathrin coat assemblyIEAbiological_process
GO:0060391Positive regulation of SMAD protein import into nucleusIDAbiological_process
GO:0060766Negative regulation of androgen receptor signaling pathwayIMPbiological_process
GO:0070022Transforming growth factor beta receptor homodimeric complexIDAcellular_component
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:1900026Positive regulation of substrate adhesion-dependent cell spreadingIEAbiological_process
GO:2000096Positive regulation of Wnt signaling pathway, planar cell polarity pathwayIMPbiological_process
GO:2000370Positive regulation of clathrin-mediated endocytosisIEA IMPbiological_process
GO:2000643Positive regulation of early endosome to late endosome transportIMPbiological_process
GO:2001046Positive regulation of integrin-mediated signaling pathwayIEAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04177271760.05759156570.45746253110.4512853826

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6046545658
GSE13712_SHEARUp0.5248489047
GSE13712_STATICUp0.0437636319
GSE19018Up0.4599012041
GSE19899_A1Down-1.2274639248
GSE19899_A2Down-0.3649151833
PubMed_21979375_A1Down-1.5686838856
PubMed_21979375_A2Down-0.7381735258
GSE35957Up0.7126681807
GSE36640Up0.7815852733
GSE54402Down-1.0698088991
GSE9593Up1.6616203954
GSE43922Down-0.7310717498
GSE24585Up1.6746568062
GSE37065Down-0.0796307527
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1675689550

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018855MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT030166MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24073285The DOC-2/DAB2 interactive protein (DAB2IP) is a new member of the Ras GTPase-activating protein family
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