HCSGD entry for AARS
1. General information
| Official gene symbol | AARS |
|---|---|
| Entrez ID | 16 |
| Gene full name | alanyl-tRNA synthetase |
| Other gene symbols | CMT2N |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IEA | molecular_function |
| GO:0001942 | Hair follicle development | IEA | biological_process |
| GO:0002161 | Aminoacyl-tRNA editing activity | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0004813 | Alanine-tRNA ligase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006400 | TRNA modification | IEA | biological_process |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006419 | Alanyl-tRNA aminoacylation | IEA | biological_process |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0008033 | TRNA processing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0021680 | Cerebellar Purkinje cell layer development | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IEA | biological_process |
| GO:0043200 | Response to amino acid | IEA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050885 | Neuromuscular process controlling balance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6471721135 | 0.0090998746 | 0.9999902473 | 0.1887750197 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3038165771 |
| GSE13712_SHEAR | Down | -0.2481806022 |
| GSE13712_STATIC | Down | -0.3614260005 |
| GSE19018 | Up | 0.9688181577 |
| GSE19899_A1 | Down | -0.8735073785 |
| GSE19899_A2 | Down | -1.3727514211 |
| PubMed_21979375_A1 | Down | -1.4841722496 |
| PubMed_21979375_A2 | Down | -0.7834294230 |
| GSE35957 | Down | -0.7354015093 |
| GSE36640 | Down | -0.5243129420 |
| GSE54402 | Down | -0.7810219771 |
| GSE9593 | Down | -0.3234524902 |
| GSE43922 | Down | -0.3540477991 |
| GSE24585 | Up | 0.4084823592 |
| GSE37065 | Down | -0.3591612904 |
| GSE28863_A1 | Up | 0.6114084855 |
| GSE28863_A2 | Up | 0.2518960627 |
| GSE28863_A3 | Down | -0.3173253416 |
| GSE28863_A4 | Up | 0.1233567055 |
| GSE48662 | Up | 0.3293737625 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Alanine | DB00160 | NUTR00013 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022529 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037527 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038499 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039031 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039826 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041325 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041952 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043224 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043527 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
