HCSGD entry for CYP51A1
1. General information
| Official gene symbol | CYP51A1 |
|---|---|
| Entrez ID | 1595 |
| Gene full name | cytochrome P450, family 51, subfamily A, polypeptide 1 |
| Other gene symbols | CP51 CYP51 CYPL1 LDM P450-14DM P450L1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004497 | Monooxygenase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006694 | Steroid biosynthetic process | IDA | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008398 | Sterol 14-demethylase activity | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0020037 | Heme binding | IDA IEA | molecular_function |
| GO:0033488 | Cholesterol biosynthetic process via 24,25-dihydrolanosterol | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070988 | Demethylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9087690779 | 0.6331069526 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Up | 0.4232187649 |
| GSE24585 | Down | -0.0635874523 |
| GSE37065 | Up | 0.0624714338 |
| GSE28863_A1 | Down | -0.0431432530 |
| GSE28863_A2 | Up | 0.0914113710 |
| GSE28863_A3 | Down | -0.0739141117 |
| GSE28863_A4 | Down | -0.1426421815 |
| GSE48662 | Down | -0.0940653311 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tioconazole | DB01007 | APRD01262 |
| Rifampicin | DB01045 | APRD00207 | EXPT02777 |
| Itraconazole | DB01167 | APRD00040 |
| 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE | DB07705 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001555 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018801 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025395 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046448 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
