HCSGD entry for ADSL
1. General information
| Official gene symbol | ADSL |
|---|---|
| Entrez ID | 158 |
| Gene full name | adenylosuccinate lyase |
| Other gene symbols | AMPS ASASE ASL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004018 | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | IDA IEA TAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006164 | Purine nucleotide biosynthetic process | IC | biological_process |
| GO:0006167 | AMP biosynthetic process | IDA | biological_process |
| GO:0006189 | 'de novo' IMP biosynthetic process | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0009060 | Aerobic respiration | IEA | biological_process |
| GO:0009152 | Purine ribonucleotide biosynthetic process | IEA | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0014850 | Response to muscle activity | IEA | biological_process |
| GO:0042594 | Response to starvation | IEA | biological_process |
| GO:0044208 | 'de novo' AMP biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051262 | Protein tetramerization | IDA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0070626 | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9910118954 | 0.0087247065 | 0.9999902473 | 0.1860506883 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0674774902 |
| GSE13712_SHEAR | Down | -0.4482042795 |
| GSE13712_STATIC | Down | -0.1107528951 |
| GSE19018 | Down | -0.2107780795 |
| GSE19899_A1 | Down | -0.3939144504 |
| GSE19899_A2 | Down | -0.3579578949 |
| PubMed_21979375_A1 | Down | -0.5349446294 |
| PubMed_21979375_A2 | Down | -0.3208283072 |
| GSE35957 | Down | -0.4237491922 |
| GSE36640 | Down | -0.9334106874 |
| GSE54402 | Up | 0.1422914974 |
| GSE9593 | Down | -0.3182616931 |
| GSE43922 | Up | 0.0024259640 |
| GSE24585 | Down | -0.5177460831 |
| GSE37065 | Down | -0.3716126137 |
| GSE28863_A1 | Down | -0.1957145116 |
| GSE28863_A2 | Down | -0.0806842122 |
| GSE28863_A3 | Down | -0.8323996754 |
| GSE28863_A4 | Up | 0.2699994511 |
| GSE48662 | Down | -0.3430813721 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-3p | MIMAT0004509 | MIRT038883 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052539 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
