HCSGD entry for CYP3A4

1. General information

Official gene symbolCYP3A4
Entrez ID1576
Gene full namecytochrome P450, family 3, subfamily A, polypeptide 4
Other gene symbolsCP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityIDA IEA ISSmolecular_function
GO:0005496Steroid bindingIDAmolecular_function
GO:0005506Iron ion bindingIDA IEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006629Lipid metabolic processTASbiological_process
GO:0006706Steroid catabolic processIMPbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008202Steroid metabolic processIMPbiological_process
GO:0008209Androgen metabolic processTASbiological_process
GO:0008395Steroid hydroxylase activityIMPmolecular_function
GO:0009822Alkaloid catabolic processIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016098Monoterpenoid metabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0017144Drug metabolic processIDAbiological_process
GO:0019825Oxygen bindingTASmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0030343Vitamin D3 25-hydroxylase activityIDAmolecular_function
GO:0033780Taurochenodeoxycholate 6alpha-hydroxylase activityIEAmolecular_function
GO:0034875Caffeine oxidase activityIDAmolecular_function
GO:0036378Calcitriol biosynthetic process from calciolIDAbiological_process
GO:0042359Vitamin D metabolic processICbiological_process
GO:0042737Drug catabolic processIDA IMPbiological_process
GO:0042738Exogenous drug catabolic processIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046483Heterocycle metabolic processIDAbiological_process
GO:0047638Albendazole monooxygenase activityIEAmolecular_function
GO:0050591Quinine 3-monooxygenase activityIEAmolecular_function
GO:0050649Testosterone 6-beta-hydroxylase activityIMPmolecular_function
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070576Vitamin D 24-hydroxylase activityIDAmolecular_function
GO:0070989Oxidative demethylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13961639380.92921081650.75165536921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0068609468
GSE13712_SHEARUp0.0510932742
GSE13712_STATICDown-0.0509091704
GSE19018Down-0.0024752593
GSE19899_A1Up0.1951607146
GSE19899_A2Up0.6243731871
PubMed_21979375_A1Up0.3909250701
PubMed_21979375_A2Up0.3888570751
GSE35957Up0.0818280957
GSE36640Up0.0517911927
GSE54402Up0.4801563145
GSE9593Down-0.0004414252
GSE43922Up0.9878507007
GSE24585Down-0.2435721004
GSE37065Down-0.0543181931
GSE28863_A1Down-0.2197878782
GSE28863_A2Up0.0468959588
GSE28863_A3Up0.0047628826
GSE28863_A4Down-0.0478360275
GSE48662Up0.1948991108

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsoniazidDB00951 APRD01055 | EXPT01940
PaliperidoneDB01267 -
Pradefovir MesylateDB05478 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-27b-3pMIMAT0000419MIRT006510Immunoblot//Luciferase reporter assayFunctional MTI19581388
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.