HCSGD entry for CYP2E1

1. General information

Official gene symbolCYP2E1
Entrez ID1571
Gene full namecytochrome P450, family 2, subfamily E, polypeptide 1
Other gene symbolsCPE1 CYP2E P450-J P450C2E
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0004497Monooxygenase activityIDA IEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008202Steroid metabolic processIMPbiological_process
GO:0010193Response to ozoneIEAbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0016098Monoterpenoid metabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0016709Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenTASmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0017144Drug metabolic processIDA IMPbiological_process
GO:0019825Oxygen bindingTASmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0020037Heme bindingIDA IEAmolecular_function
GO:0031227Intrinsic component of endoplasmic reticulum membraneIEAcellular_component
GO:0042493Response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0046483Heterocycle metabolic processIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07833077010.96572525360.59059954181.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0562808435
GSE13712_SHEARUp0.0960209825
GSE13712_STATICDown-0.0189014990
GSE19018Down-0.0113339522
GSE19899_A1Up0.1237806674
GSE19899_A2Up0.2785955595
PubMed_21979375_A1Up0.9800081904
PubMed_21979375_A2Up0.4210798087
GSE35957Up0.2538537417
GSE36640Up0.4752123471
GSE54402Up0.1543131342
GSE9593Down-0.0604101507
GSE43922Up0.0486209986
GSE24585Up0.1591700712
GSE37065Up0.3085434046
GSE28863_A1Down-0.0853482758
GSE28863_A2Down-0.1108150266
GSE28863_A3Down-0.1718541897
GSE28863_A4Up0.4980818360
GSE48662Down-0.0983163503

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017817MicroarrayFunctional MTI (Weak)18185580
hsa-miR-132-3pMIMAT0000426MIRT021813MicroarrayFunctional MTI (Weak)17612493
hsa-miR-488-3pMIMAT0004763MIRT038008CLASHFunctional MTI (Weak)23622248
hsa-miR-488-5pMIMAT0002804MIRT041622CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.