HCSGD entry for CYP2C19
1. General information
| Official gene symbol | CYP2C19 |
|---|---|
| Entrez ID | 1557 |
| Gene full name | cytochrome P450, family 2, subfamily C, polypeptide 19 |
| Other gene symbols | CPCJ CYP2C P450C2C P450IIC19 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004497 | Monooxygenase activity | IDA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | IMP | biological_process |
| GO:0008395 | Steroid hydroxylase activity | IMP | molecular_function |
| GO:0016098 | Monoterpenoid metabolic process | IDA | biological_process |
| GO:0016491 | Oxidoreductase activity | IDA | molecular_function |
| GO:0017144 | Drug metabolic process | IDA | biological_process |
| GO:0018675 | (S)-limonene 6-monooxygenase activity | IEA | molecular_function |
| GO:0018676 | (S)-limonene 7-monooxygenase activity | IEA | molecular_function |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019373 | Epoxygenase P450 pathway | TAS | biological_process |
| GO:0019825 | Oxygen binding | TAS | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0020037 | Heme binding | IDA | molecular_function |
| GO:0042738 | Exogenous drug catabolic process | IDA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046483 | Heterocycle metabolic process | IDA | biological_process |
| GO:0052741 | (R)-limonene 6-monooxygenase activity | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:0097267 | Omega-hydroxylase P450 pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6477884769 | 0.7246889974 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1158438662 |
| GSE13712_SHEAR | Down | -0.0087123660 |
| GSE13712_STATIC | Down | -0.2240247798 |
| GSE19018 | Up | 0.0763430858 |
| GSE19899_A1 | Up | 0.1437589881 |
| GSE19899_A2 | Down | -0.1135431023 |
| PubMed_21979375_A1 | Up | 0.1948074397 |
| PubMed_21979375_A2 | Down | -0.4371500128 |
| GSE35957 | Up | 0.4694800676 |
| GSE36640 | Down | -0.1362691454 |
| GSE54402 | Up | 0.0406443050 |
| GSE9593 | Up | 0.3183433318 |
| GSE43922 | Up | 0.0020598840 |
| GSE24585 | Down | -0.1552889276 |
| GSE37065 | Up | 0.0216101919 |
| GSE28863_A1 | Down | -0.0275287939 |
| GSE28863_A2 | Up | 0.0254945382 |
| GSE28863_A3 | Up | 0.1364768684 |
| GSE28863_A4 | Down | -0.0349308613 |
| GSE48662 | Up | 0.0589241182 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isoniazid | DB00951 | APRD01055 | EXPT01940 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
