HCSGD entry for CYP1A1

1. General information

Official gene symbolCYP1A1
Entrez ID1543
Gene full namecytochrome P450, family 1, subfamily A, polypeptide 1
Other gene symbolsAHH AHRR CP11 CYP1 P1-450 P450-C P450DX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006778Porphyrin-containing compound metabolic processIEAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008395Steroid hydroxylase activityIEAmolecular_function
GO:0009308Amine metabolic processIEAbiological_process
GO:0009611Response to woundingIEAbiological_process
GO:0009615Response to virusIEAbiological_process
GO:0009624Response to nematodeIEAbiological_process
GO:0009635Response to herbicideIEAbiological_process
GO:0009792Embryo development ending in birth or egg hatchingIEAbiological_process
GO:0009804Coumarin metabolic processIEAbiological_process
GO:0009812Flavonoid metabolic processIEAbiological_process
GO:0010041Response to iron(III) ionIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0016679Oxidoreductase activity, acting on diphenols and related substances as donorsIEAmolecular_function
GO:0016711Flavonoid 3'-monooxygenase activityIEAmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0017143Insecticide metabolic processIEAbiological_process
GO:0017144Drug metabolic processIDAbiological_process
GO:0019341Dibenzo-p-dioxin catabolic processIEAbiological_process
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019373Epoxygenase P450 pathwayTASbiological_process
GO:0019825Oxygen bindingTASmolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0032094Response to foodIEAbiological_process
GO:0032451Demethylase activityIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0042359Vitamin D metabolic processICbiological_process
GO:0042493Response to drugIEAbiological_process
GO:00429049-cis-retinoic acid biosynthetic processIEAbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046677Response to antibioticIEAbiological_process
GO:0046685Response to arsenic-containing substanceIEAbiological_process
GO:0048565Digestive tract developmentIEAbiological_process
GO:0050665Hydrogen peroxide biosynthetic processIEAbiological_process
GO:0055093Response to hyperoxiaIEAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0060137Maternal process involved in parturitionIEAbiological_process
GO:0070330Aromatase activityIEAmolecular_function
GO:0070365Hepatocyte differentiationIEAbiological_process
GO:0070576Vitamin D 24-hydroxylase activityIDAmolecular_function
GO:0097267Omega-hydroxylase P450 pathwayTASbiological_process
GO:1900087Positive regulation of G1/S transition of mitotic cell cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03432118080.03948167240.42582313850.3746204398

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3371662627
GSE13712_SHEARDown-6.9766619287
GSE13712_STATICDown-4.2597114460
GSE19018Down-0.1218593399
GSE19899_A1Up0.1930084353
GSE19899_A2Up1.2156774377
PubMed_21979375_A1Up0.8633304949
PubMed_21979375_A2Up1.1860125174
GSE35957Down-0.3003719132
GSE36640Up0.0899725612
GSE54402Up0.3015842140
GSE9593Up0.0935491700
GSE43922Up0.2642166403
GSE24585Up0.2869730134
GSE37065Down-0.0694295236
GSE28863_A1Down-0.1643965635
GSE28863_A2Up0.0449356865
GSE28863_A3Up0.0728506996
GSE28863_A4Up0.0032471489
GSE48662Down-0.0650710588

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-MethoxyestradiolDB02342 EXPT01362

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-3pMIMAT0004679MIRT038448CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24885022Further, we presented evidence suggesting that neither endogenous AhR expression levels nor downstream induction of AhR target genes CYP1A1 and CYP1B1 is required for AF-mediated growth inhibition in these cells
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