HCSGD entry for CYLD
1. General information
| Official gene symbol | CYLD |
|---|---|
| Entrez ID | 1540 |
| Gene full name | cylindromatosis (turban tumor syndrome) |
| Other gene symbols | BRSS CDMT CYLD1 CYLDI EAC MFT MFT1 SBS TEM USPL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002181 | Cytoplasmic translation | IBA | biological_process |
| GO:0003735 | Structural constituent of ribosome | IBA | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005881 | Cytoplasmic microtubule | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007346 | Regulation of mitotic cell cycle | IMP | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0032480 | Negative regulation of type I interferon production | TAS | biological_process |
| GO:0035872 | Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | TAS | biological_process |
| GO:0042347 | Negative regulation of NF-kappaB import into nucleus | IDA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0061578 | Lys63-specific deubiquitinase activity | IDA | molecular_function |
| GO:0070064 | Proline-rich region binding | IPI | molecular_function |
| GO:0070266 | Necroptotic process | IBA | biological_process |
| GO:0070423 | Nucleotide-binding oligomerization domain containing signaling pathway | TAS | biological_process |
| GO:0070507 | Regulation of microtubule cytoskeleton organization | IMP | biological_process |
| GO:0070536 | Protein K63-linked deubiquitination | IDA | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IMP | biological_process |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
| GO:2001242 | Regulation of intrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0271607082 | 0.8728114509 | 0.3830952330 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4255989240 |
| GSE13712_SHEAR | Down | -0.2159861652 |
| GSE13712_STATIC | Up | 0.0910734492 |
| GSE19018 | Up | 0.2417805019 |
| GSE19899_A1 | Down | -0.1120935749 |
| GSE19899_A2 | Up | 0.0157511420 |
| PubMed_21979375_A1 | Down | -0.5819936860 |
| PubMed_21979375_A2 | Up | 0.0618412420 |
| GSE35957 | Up | 0.5008876578 |
| GSE36640 | Up | 0.7186127488 |
| GSE54402 | Down | -0.1261469114 |
| GSE9593 | Up | 0.6253817549 |
| GSE43922 | Down | -0.0153007791 |
| GSE24585 | Down | -0.0230326003 |
| GSE37065 | Up | 0.5947259672 |
| GSE28863_A1 | Up | 0.9220025307 |
| GSE28863_A2 | Up | 1.2270859543 |
| GSE28863_A3 | Down | -0.2038532995 |
| GSE28863_A4 | Down | -0.1004288675 |
| GSE48662 | Up | 0.2580882907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004211 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT005595 | Luciferase reporter assay//qRT-PCR | Functional MTI | 20797623 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT006978 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23006329 |
| hsa-miR-320a | MIMAT0000510 | MIRT044462 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
