HCSGD entry for CYBB

1. General information

Official gene symbolCYBB
Entrez ID1536
Gene full namecytochrome b-245, beta polypeptide
Other gene symbolsAMCBX2 CGD GP91-1 GP91-PHOX GP91PHOX NOX2 p91-PHOX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005244Voltage-gated ion channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006801Superoxide metabolic processIDA TASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0009055Electron carrier activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016175Superoxide-generating NADPH oxidase activityIDA TASmolecular_function
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0020037Heme bindingIMPmolecular_function
GO:0030425DendriteIEAcellular_component
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0042493Response to drugIEAbiological_process
GO:0042554Superoxide anion generationIDA TASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043020NADPH oxidase complexIDA IEA TAScellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045087Innate immune responseIMP TASbiological_process
GO:0045730Respiratory burstIMP TASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050660Flavin adenine dinucleotide bindingIMPmolecular_function
GO:0050665Hydrogen peroxide biosynthetic processIEAbiological_process
GO:0051701Interaction with hostTASbiological_process
GO:0055114Oxidation-reduction processIDA TASbiological_process
GO:0090382Phagosome maturationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92611439160.14437080280.99999024730.7317346554

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0132920144
GSE13712_SHEARDown-0.1643649301
GSE13712_STATICDown-0.0135305982
GSE19018Up0.1155274486
GSE19899_A1Up0.1563472468
GSE19899_A2Down-0.0779296685
PubMed_21979375_A1Down-0.4385162630
PubMed_21979375_A2Down-0.2126800113
GSE35957Up0.0565049058
GSE36640Up0.1160404206
GSE54402Down-0.1430277539
GSE9593Up0.0919757858
GSE43922Up0.0165754296
GSE24585Down-0.9932684949
GSE37065Up0.0270292076
GSE28863_A1Down-0.2750830749
GSE28863_A2Down-0.4456746502
GSE28863_A3Up0.1815390320
GSE28863_A4Up0.1170521664
GSE48662Up0.0286251808

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DextromethorphanDB00514 APRD00655

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27057461As a part of cellular pathogen defense, IFNgamma triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells
25922068Here, we utilized a p47(phox) knock-out mouse model, in which an essential cytosolic co-activator of Nox2 is lost, to characterize bone metabolism at 6 weeks and 2 years of age
25922068Compared with their age-matched wild type controls, loss of Nox2 function in p47(phox-/-) mice resulted in age-related switch of bone mass and strength
23997094In aorta from wild-type mice, antioxidant expression was preserved, although there were age-associated increases in Nox2 expression
23997094Haploinsufficiency of MnSOD did not alter antioxidant expression in aorta, but increased expression of Nox2
23997094When compared with that of aorta, age-associated reductions in antioxidant expression were larger in aortic valves from wild-type and MnSOD haploinsufficient mice, although Nox2 expression was unchanged
21841319NOX2 and NOX4 were correlated with the late and slow phase and contributed greatly to EPCs senescence
19681754Noxs (NADPH oxidases) are well-known sources of superoxide, which contribute to the antimicrobial capabilities of macrophages, a process involving the prototypical member of the family referred to as Nox2
19681754However, in recent years non-phagocytic homologues of Nox2 have been identified that are involved in processes other than the host defence
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