HCSGD entry for ADRB1

1. General information

Official gene symbol	ADRB1
Entrez ID	153
Gene full name	adrenoceptor beta 1
Other gene symbols	ADRB1R B1AR BETA1AR RHR
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001996	Positive regulation of heart rate by epinephrine-norepinephrine	IEA	biological_process
GO:0002024	Diet induced thermogenesis	IEA	biological_process
GO:0002025	Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	IEA	biological_process
GO:0003061	Positive regulation of the force of heart contraction by norepinephrine	IEA	biological_process
GO:0003084	Positive regulation of systemic arterial blood pressure	IEA	biological_process
GO:0004939	Beta-adrenergic receptor activity	TAS	molecular_function
GO:0004940	Beta1-adrenergic receptor activity	IEA	molecular_function
GO:0005057	Receptor signaling protein activity	IDA	molecular_function
GO:0005088	Ras guanyl-nucleotide exchange factor activity	IDA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005634	Nucleus	IEA	cellular_component
GO:0005769	Early endosome	IDA	cellular_component
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	TAS	cellular_component
GO:0005980	Glycogen catabolic process	IEA	biological_process
GO:0006915	Apoptotic process	IEA	biological_process
GO:0007190	Activation of adenylate cyclase activity	TAS	biological_process
GO:0007266	Rho protein signal transduction	IEA	biological_process
GO:0007568	Aging	IEA	biological_process
GO:0007613	Memory	IEA	biological_process
GO:0008144	Drug binding	IEA	molecular_function
GO:0009409	Response to cold	IEA	biological_process
GO:0019233	Sensory perception of pain	IEA	biological_process
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030819	Positive regulation of cAMP biosynthetic process	IDA	biological_process
GO:0031649	Heat generation	IEA	biological_process
GO:0031694	Alpha-2A adrenergic receptor binding	IPI	molecular_function
GO:0032320	Positive regulation of Ras GTPase activity	IDA	biological_process
GO:0033365	Protein localization to organelle	IEA	biological_process
GO:0035240	Dopamine binding	IEA	molecular_function
GO:0035811	Negative regulation of urine volume	IEA	biological_process
GO:0040015	Negative regulation of multicellular organism growth	IEA	biological_process
GO:0042060	Wound healing	IEA	biological_process
GO:0042596	Fear response	IEA	biological_process
GO:0043065	Positive regulation of apoptotic process	IEA	biological_process
GO:0043950	Positive regulation of cAMP-mediated signaling	IDA	biological_process
GO:0045986	Negative regulation of smooth muscle contraction	IEA	biological_process
GO:0046878	Positive regulation of saliva secretion	IEA	biological_process
GO:0046982	Protein heterodimerization activity	IPI	molecular_function
GO:0050873	Brown fat cell differentiation	IEA	biological_process
GO:0051379	Epinephrine binding	IEA	molecular_function
GO:0051380	Norepinephrine binding	IEA	molecular_function
GO:0051924	Regulation of calcium ion transport	IEA	biological_process
GO:0055088	Lipid homeostasis	IEA	biological_process
GO:0060080	Regulation of inhibitory postsynaptic membrane potential	IEA	biological_process
GO:0061051	Positive regulation of cell growth involved in cardiac muscle cell development	IEA	biological_process
GO:0071880	Adenylate cyclase-activating adrenergic receptor signaling pathway	IDA	biological_process
GO:0086004	Regulation of cardiac muscle cell contraction	IEA	biological_process
GO:1900135	Positive regulation of renin secretion into blood stream	IEA	biological_process
GO:2001259	Positive regulation of cation channel activity	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.1038177083	0.9757432848	0.6697514461	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0035000229
GSE13712_SHEAR	Up	1.5473857768
GSE13712_STATIC	Up	0.6778228287
GSE19018	Up	0.1798916482
GSE19899_A1	Up	0.0429935076
GSE19899_A2	Up	0.1213549051
PubMed_21979375_A1	Up	0.0297765901
PubMed_21979375_A2	Down	-0.0790732386
GSE35957	Up	0.0564480956
GSE36640	Down	-0.0881865829
GSE54402	Up	0.2562216583
GSE9593	Up	0.1462460019
GSE43922	Up	0.0730336110
GSE24585	Up	0.1114311862
GSE37065	Down	-0.0879167127
GSE28863_A1	Up	0.0065953850
GSE28863_A2	Up	0.0618194905
GSE28863_A3	Up	0.2182243483
GSE28863_A4	Up	0.1117449526
GSE48662	Up	0.0923396486

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results