HCSGD entry for KLB
1. General information
| Official gene symbol | KLB |
|---|---|
| Entrez ID | 152831 |
| Gene full name | klotho beta |
| Other gene symbols | BKL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004553 | Hydrolase activity, hydrolyzing O-glycosyl compounds | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017134 | Fibroblast growth factor binding | IPI | molecular_function |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0090080 | Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5098047795 | 0.7868502640 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1682282779 |
| GSE13712_SHEAR | Up | 0.1442508627 |
| GSE13712_STATIC | Up | 0.0155019653 |
| GSE19018 | Up | 0.0985761314 |
| GSE19899_A1 | Up | 0.1260472776 |
| GSE19899_A2 | Up | 0.1025484895 |
| PubMed_21979375_A1 | Down | -0.3026649382 |
| PubMed_21979375_A2 | Down | -0.0047635722 |
| GSE35957 | Up | 0.0573189011 |
| GSE36640 | Down | -0.1425462662 |
| GSE54402 | Up | 0.2195198033 |
| GSE9593 | Down | -1.3530571621 |
| GSE43922 | Up | 0.0190617994 |
| GSE24585 | Up | 0.1148581019 |
| GSE37065 | Down | -0.0486776059 |
| GSE28863_A1 | Up | 0.0133792899 |
| GSE28863_A2 | Up | 0.1151848133 |
| GSE28863_A3 | Up | 0.1485062915 |
| GSE28863_A4 | Up | 0.0037304681 |
| GSE48662 | Up | 0.1016770403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT006874 | Luciferase reporter assay | Functional MTI | 22988100 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048903 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
