HCSGD entry for CX3CR1

1. General information

Official gene symbolCX3CR1
Entrez ID1524
Gene full namechemokine (C-X3-C motif) receptor 1
Other gene symbolsCCRL1 CMKBRL1 CMKDR1 GPR13 GPRV28 V28
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0004950Chemokine receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006935ChemotaxisTASbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0009611Response to woundingTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0016495C-X3-C chemokine receptor activityIEAmolecular_function
GO:0016525Negative regulation of angiogenesisIEAbiological_process
GO:0021795Cerebral cortex cell migrationIEAbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0032809Neuronal cell body membraneIEAcellular_component
GO:0043005Neuron projectionIEAcellular_component
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0048246Macrophage chemotaxisIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0070098Chemokine-mediated signaling pathwayTASbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25947448430.89715870220.95305999161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0428677744
GSE13712_SHEARDown-0.0154592593
GSE13712_STATICDown-0.0572120351
GSE19018Up0.1680506993
GSE19899_A1Up0.1754708558
GSE19899_A2Up0.0941700932
PubMed_21979375_A1Up0.2753320607
PubMed_21979375_A2Up0.0579017613
GSE35957Up0.0772995425
GSE36640Up0.0949778958
GSE54402Up0.1139282600
GSE9593Up0.1378972684
GSE43922Down-0.0301799612
GSE24585Up0.1205136486
GSE37065Down-0.1634756687
GSE28863_A1Down-0.3940000834
GSE28863_A2Up0.5068288027
GSE28863_A3Up0.1605698964
GSE28863_A4Up0.0235933575
GSE48662Up0.5169129783

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24185682METHODS: We examined immunohistochemically the expression of CCR2, CX3CR1, CCL2 and CX3CL1 in livers taken from the patients with PBC (n = 45) and control livers (n = 78), such as chronic viral hepatitis (CVH; n = 39)
16461801Such regulatory receptors include stimulatory and inhibitory members of the killer immunoglobulin-like receptor (KIR) family, the stimulatory c-type lectin receptor NKG2D, and CX3CR1, the receptor for the chemokine fractalkine
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