HCSGD entry for CUX1

1. General information

Official gene symbolCUX1
Entrez ID1523
Gene full namecut-like homeobox 1
Other gene symbolsCASP CDP CDP/Cut CDP1 COY1 CUTL1 CUX Clox Cux/CDP GOLIM6 Nbla10317 p100 p110 p200 p75
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0000301Retrograde transport, vesicle recycling within GolgiIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006891Intra-Golgi vesicle-mediated transportIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0030173Integral component of Golgi membraneIEAcellular_component
GO:0030324Lung developmentIEAbiological_process
GO:0030674Protein binding, bridgingIEAmolecular_function
GO:0042491Auditory receptor cell differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17995112650.16191911780.83150010530.7772885464

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.0013507543
GSE13712_SHEARDown-0.2193964005
GSE13712_STATICDown-0.2462904987
GSE19018Down-0.2552378908
GSE19899_A1Down-0.3532979837
GSE19899_A2Up0.0691311149
PubMed_21979375_A1Up0.1520806523
PubMed_21979375_A2Up0.6484776366
GSE35957Up0.8987813496
GSE36640Up0.1105775582
GSE54402Down-0.3339521356
GSE9593Up0.0131767209
GSE43922Down-0.0556122103
GSE24585Up0.0481215410
GSE37065Up0.0808146491
GSE28863_A1Up0.8658748192
GSE28863_A2Up1.0326509061
GSE28863_A3Up0.0191423239
GSE28863_A4Down-0.2445821095
GSE48662Up0.0148728247

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT004087Microarray//qRT-PCRFunctional MTI (Weak)19193853
hsa-miR-155-5pMIMAT0000646MIRT004087pSILACFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT036826CLASHFunctional MTI (Weak)23622248
hsa-miR-455-3pMIMAT0004784MIRT037836CLASHFunctional MTI (Weak)23622248
hsa-miR-18b-5pMIMAT0001412MIRT042405CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT048935CLASH//qRT-PCRFunctional MTI (WeaK)23622248
hsa-let-7b-5pMIMAT0000063MIRT052342CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25682875The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
25682875Here we show that Cux1-/- MEFs are unable to proliferate in atmospheric (20%) oxygen although they can proliferate normally in physiological (3%) oxygen levels
25682875CUX1 contains three domains called Cut repeats
25682875Repair of oxidative DNA damage and proliferation in 20% oxygen were both rescued in Cux1-/- MEFs by ectopic expression of CUX1 or of a recombinant Cut repeat protein that stimulates OGG1 but is devoid of transcription activation potential
25682875These findings reinforce the causal link between oxidative DNA damage and cellular senescence and suggest that the role of CUX1 as an accessory factor in DNA repair will be critical in physiological situations that generate higher levels of reactive oxygen species
24618719The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival
24618719The dual role of CUX1 in cancer is illustrated by the fact that most cell lines with CUX1 LOH display amplification of the remaining allele, suggesting that decreased CUX1 expression facilitates tumor development while increased CUX1 expression is needed in tumorigenic cells
24618719Indeed, CUX1 was found in a genome-wide RNAi screen to identify synthetic lethal interactions with oncogenic RAS
24618719Here we show that CUX1 functions in base excision repair as an ancillary factor for the 8-oxoG-DNA glycosylase, OGG1
24618719Single cell gel electrophoresis (comet assay) reveals that Cux1(+)/(-) MEFs are haploinsufficient for the repair of oxidative DNA damage, whereas elevated CUX1 levels accelerate DNA repair
24618719In vitro base excision repair assays with purified components demonstrate that CUX1 directly stimulates OGG1's enzymatic activity
24618719We show that elevated expression of either CUX1 or OGG1 prevents RAS-induced senescence in primary cells, and that CUX1 knockdown is synthetic lethal with oncogenic RAS in human cancer cells
24618719Elevated CUX1 expression in a transgenic mouse model enables the emergence of mammary tumors with spontaneous activating Kras mutations
24618719We confirmed cooperation between Kras(G12V) and CUX1 in a lung tumor model
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