HCSGD entry for ADRA2C

1. General information

Official gene symbol	ADRA2C
Entrez ID	152
Gene full name	adrenoceptor alpha 2C
Other gene symbols	ADRA2L2 ADRA2RL2 ADRARL2 ALPHA2CAR
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0004938	Alpha2-adrenergic receptor activity	IDA IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005768	Endosome	TAS	cellular_component
GO:0005886	Plasma membrane	IEA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	IDA	cellular_component
GO:0006112	Energy reserve metabolic process	TAS	biological_process
GO:0006940	Regulation of smooth muscle contraction	IEA	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	TAS	biological_process
GO:0007267	Cell-cell signaling	TAS	biological_process
GO:0007565	Female pregnancy	IEA	biological_process
GO:0007596	Blood coagulation	TAS	biological_process
GO:0010700	Negative regulation of norepinephrine secretion	NAS TAS	biological_process
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0019229	Regulation of vasoconstriction	IEA	biological_process
GO:0030168	Platelet activation	IEA TAS	biological_process
GO:0031694	Alpha-2A adrenergic receptor binding	IPI	molecular_function
GO:0032148	Activation of protein kinase B activity	IDA	biological_process
GO:0032811	Negative regulation of epinephrine secretion	NAS	biological_process
GO:0035625	Epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	IDA	biological_process
GO:0042803	Protein homodimerization activity	IDA	molecular_function
GO:0043679	Axon terminus	IEA	cellular_component
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0045666	Positive regulation of neuron differentiation	IDA	biological_process
GO:0045907	Positive regulation of vasoconstriction	IEA	biological_process
GO:0046982	Protein heterodimerization activity	IPI	molecular_function
GO:0050796	Regulation of insulin secretion	TAS	biological_process
GO:0051379	Epinephrine binding	IDA	molecular_function
GO:0051930	Regulation of sensory perception of pain	IEA	biological_process
GO:0070473	Negative regulation of uterine smooth muscle contraction	IEA	biological_process
GO:0071883	Activation of MAPK activity by adrenergic receptor signaling pathway	IDA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.2233309107	0.7223824703	0.9040289793	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.0688752252
GSE13712_SHEAR	Up	0.0550488194
GSE13712_STATIC	Down	-0.1364332090
GSE19018	Up	0.2362328096
GSE19899_A1	Up	0.0571459278
GSE19899_A2	Up	0.4644828429
PubMed_21979375_A1	Up	0.2547167556
PubMed_21979375_A2	Up	0.0766286607
GSE35957	Up	0.2644281434
GSE36640	Up	0.7735137962
GSE54402	Up	0.1186718121
GSE9593	Down	-0.1003979873
GSE43922	Up	0.0527892779
GSE24585	Down	-0.0125889900
GSE37065	Down	-0.1140500202
GSE28863_A1	Down	-0.2847891606
GSE28863_A2	Down	-0.3311411289
GSE28863_A3	Up	0.3768490276
GSE28863_A4	Down	-0.0429073678
GSE48662	Down	-0.2244810714

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results