HCSGD entry for PPM1L
1. General information
| Official gene symbol | PPM1L |
|---|---|
| Entrez ID | 151742 |
| Gene full name | protein phosphatase, Mg2+/Mn2+ dependent, 1L |
| Other gene symbols | PP2C-epsilon PP2CE PPM1-LIKE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0004722 | Protein serine/threonine phosphatase activity | TAS | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IEA | biological_process |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0007178 | Transmembrane receptor protein serine/threonine kinase signaling pathway | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1269595380 | 0.9380799780 | 0.7256204733 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1572212883 |
| GSE13712_SHEAR | Down | -0.3509627799 |
| GSE13712_STATIC | Down | -0.1141465040 |
| GSE19018 | Up | 0.0762616345 |
| GSE19899_A1 | Up | 0.1033259346 |
| GSE19899_A2 | Up | 0.1677683597 |
| PubMed_21979375_A1 | Up | 0.3169872614 |
| PubMed_21979375_A2 | Up | 0.2964030892 |
| GSE35957 | Up | 0.0523611495 |
| GSE36640 | Up | 0.3385435059 |
| GSE54402 | Up | 0.1707730727 |
| GSE9593 | Up | 0.2098380795 |
| GSE43922 | Up | 0.5337361099 |
| GSE24585 | Up | 0.3597289019 |
| GSE37065 | Up | 0.1756925561 |
| GSE28863_A1 | Down | -0.1066588677 |
| GSE28863_A2 | Up | 0.2903482122 |
| GSE28863_A3 | Down | -0.0854121390 |
| GSE28863_A4 | Down | -0.1109692987 |
| GSE48662 | Down | -0.0079066379 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017625 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030870 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
