HCSGD entry for SGOL1
1. General information
| Official gene symbol | SGOL1 |
|---|---|
| Entrez ID | 151648 |
| Gene full name | shugoshin-like 1 (S. pombe) |
| Other gene symbols | NY-BR-85 SGO Sgo1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000779 | Condensed chromosome, centromeric region | IDA | cellular_component |
| GO:0000780 | Condensed nuclear chromosome, centromeric region | IEA | cellular_component |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007059 | Chromosome segregation | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008608 | Attachment of spindle microtubules to kinetochore | IDA | biological_process |
| GO:0010457 | Centriole-centriole cohesion | IDA | biological_process |
| GO:0030892 | Mitotic cohesin complex | IDA | cellular_component |
| GO:0045132 | Meiotic chromosome segregation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9870692565 | 0.0009724858 | 0.9999902473 | 0.0588432184 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1533881173 |
| GSE13712_SHEAR | Down | -0.1893335678 |
| GSE13712_STATIC | Down | -0.0713113916 |
| GSE19018 | Up | 0.0508761421 |
| GSE19899_A1 | Down | -0.0964449300 |
| GSE19899_A2 | Down | -1.1166313180 |
| PubMed_21979375_A1 | Down | -1.0483649123 |
| PubMed_21979375_A2 | Down | -1.2796335343 |
| GSE35957 | Down | -0.7768540935 |
| GSE36640 | Down | -3.2869440669 |
| GSE54402 | Down | -0.4089171717 |
| GSE9593 | Down | -0.4208611139 |
| GSE43922 | Down | -2.5278950067 |
| GSE24585 | Down | -0.2955285518 |
| GSE37065 | Down | -0.6454310731 |
| GSE28863_A1 | Down | -0.6434739604 |
| GSE28863_A2 | Up | 0.8671871654 |
| GSE28863_A3 | Down | -0.1561836857 |
| GSE28863_A4 | Down | -0.0945211400 |
| GSE48662 | Down | -0.5864085800 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016264 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26847209 | BACKGROUND: Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division |
| 26847209 | RESULTS: We observed that BubR1(+/-) SGO(+/-) MEFs had an accelerated cellular senescence characterized by morphological changes and expressed senescence-associated beta-galactosidase |
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