HCSGD entry for CTSH

1. General information

Official gene symbolCTSH
Entrez ID1512
Gene full namecathepsin H
Other gene symbolsACC-4 ACC-5 CPSB minichain
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001520Outer dense fiberIEAcellular_component
GO:0001656Metanephros developmentIEA ISSbiological_process
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0001913T cell mediated cytotoxicityIEA ISSbiological_process
GO:0002250Adaptive immune responseIEPbiological_process
GO:0002764Immune response-regulating signaling pathwayIDAbiological_process
GO:0004175Endopeptidase activityIDAmolecular_function
GO:0004177Aminopeptidase activityIDA IEAmolecular_function
GO:0004197Cysteine-type endopeptidase activityIDA IEA TASmolecular_function
GO:0004252Serine-type endopeptidase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006508ProteolysisIDA TASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008234Cysteine-type peptidase activityIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIEA ISSbiological_process
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processIDA IEAmolecular_function
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010634Positive regulation of epithelial cell migrationIEA ISSbiological_process
GO:0010813Neuropeptide catabolic processIDAbiological_process
GO:0010815Bradykinin catabolic processIDAbiological_process
GO:0010952Positive regulation of peptidase activityIDAbiological_process
GO:0019882Antigen processing and presentationTASbiological_process
GO:0030108HLA-A specific activating MHC class I receptor activityIDAmolecular_function
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030984Kininogen bindingIEAmolecular_function
GO:0031638Zymogen activationIDA IEAbiological_process
GO:0031648Protein destabilizationIEA IMPbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032526Response to retinoic acidIEA ISSbiological_process
GO:0033619Membrane protein proteolysisIDA IEAbiological_process
GO:0043066Negative regulation of apoptotic processIEA ISSbiological_process
GO:0043129Surfactant homeostasisIDAbiological_process
GO:0043621Protein self-associationIEAmolecular_function
GO:0045766Positive regulation of angiogenesisIEA ISSbiological_process
GO:0060448Dichotomous subdivision of terminal units involved in lung branchingIEA ISSbiological_process
GO:0070324Thyroid hormone bindingIDAmolecular_function
GO:0070371ERK1 and ERK2 cascadeIDAbiological_process
GO:0097067Cellular response to thyroid hormone stimulusIEA IEPbiological_process
GO:0097208Alveolar lamellar bodyIDAcellular_component
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15588473460.02700888260.78437050280.3138491615

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7046343576
GSE13712_SHEARDown-4.3196024911
GSE13712_STATICDown-2.0162604639
GSE19018Up0.0600097180
GSE19899_A1Up0.0596064383
GSE19899_A2Down-1.0520997535
PubMed_21979375_A1Down-0.0371099962
PubMed_21979375_A2Up0.0292619193
GSE35957Down-0.5675352360
GSE36640Down-0.2388678955
GSE54402Down-0.1435631965
GSE9593Up0.0739357934
GSE43922Down-0.4609819535
GSE24585Up0.1962011470
GSE37065Up1.0581933879
GSE28863_A1Down-0.4782244268
GSE28863_A2Up0.9304633481
GSE28863_A3Up0.2821809148
GSE28863_A4Down-0.0213702919
GSE48662Up0.0585003146

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-SuccinamideDB02140 EXPT00812
Para-Toluene SulfonateDB03120 EXPT03125
N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-ButaneDB04126 EXPT01318
CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONEDB08526 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022220MicroarrayFunctional MTI (Weak)18668037
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.