HCSGD entry for CTRL
1. General information
| Official gene symbol | CTRL |
|---|---|
| Entrez ID | 1506 |
| Gene full name | chymotrypsin-like |
| Other gene symbols | CTRL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007586 | Digestion | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8364769994 | 0.4654374682 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2351516842 |
| GSE13712_SHEAR | Down | -0.0863818171 |
| GSE13712_STATIC | Down | -0.0624403502 |
| GSE19018 | Down | -0.0850612562 |
| GSE19899_A1 | Up | 0.0393139260 |
| GSE19899_A2 | Up | 0.0981179785 |
| PubMed_21979375_A1 | Up | 0.7036882021 |
| PubMed_21979375_A2 | Up | 0.2169664630 |
| GSE35957 | Up | 0.0072420832 |
| GSE36640 | Down | -0.1596214619 |
| GSE54402 | Down | -0.0479815116 |
| GSE9593 | Down | -0.1666784110 |
| GSE43922 | Up | 0.0361767155 |
| GSE24585 | Down | -0.1556591785 |
| GSE37065 | Up | 0.1300493213 |
| GSE28863_A1 | Down | -0.0732154594 |
| GSE28863_A2 | Down | -0.1509461217 |
| GSE28863_A3 | Up | 0.0477012185 |
| GSE28863_A4 | Down | -0.0307729775 |
| GSE48662 | Down | -0.0283823032 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18817863 | Decline in chymotrypsin-like, peptidylglutamyl-peptide hydrolase and trypsin-like activities of the 20S proteasome was detected in aged RPE cells through degradation of fluorogenic substrates |
| 11099467 | During proliferative senescence, we found a marked decline in all proteasome activities (trypsin-like activity, chymotrypsin-like activity, and peptidyl-glutamyl-hydrolyzing activity) and in lysosomal cathepsin activity |
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