HCSGD entry for TTL


1. General information

Official gene symbolTTL
Entrez ID150465
Gene full nametubulin tyrosine ligase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0004835Tubulin-tyrosine ligase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006464Cellular protein modification processIEAbiological_process
GO:0030516Regulation of axon extensionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06402310700.71325091750.54513476711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3550560283
GSE13712_SHEARDown-0.0506825437
GSE13712_STATICDown-0.0598981706
GSE19018Down-0.3891936097
GSE19899_A1Up0.5518232481
GSE19899_A2Up0.3206967339
PubMed_21979375_A1Up1.1937442068
PubMed_21979375_A2Up0.5084499550
GSE35957Down-0.0467516654
GSE36640Down-0.0791672220
GSE54402Up0.6850191117
GSE9593Up0.1117027018
GSE43922Up0.7557069992
GSE24585Down-0.0504132690
GSE37065Down-0.0658907633
GSE28863_A1Down-0.2724702634
GSE28863_A2Up0.0221146103
GSE28863_A3Down-0.1795625857
GSE28863_A4Down-0.1581544160
GSE48662Down-0.2311022880

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320cMIMAT0005793MIRT036172CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036928CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038458CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045574CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049681CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.