HCSGD entry for SIK1
1. General information
| Official gene symbol | SIK1 |
|---|---|
| Entrez ID | 150094 |
| Gene full name | salt-inducible kinase 1 |
| Other gene symbols | MSK SIK SNF1LK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000287 | Magnesium ion binding | IDA ISS | molecular_function |
| GO:0002028 | Regulation of sodium ion transport | ISS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA ISS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA ISS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007346 | Regulation of mitotic cell cycle | ISS | biological_process |
| GO:0008140 | CAMP response element binding protein binding | ISS | molecular_function |
| GO:0010830 | Regulation of myotube differentiation | ISS | biological_process |
| GO:0010868 | Negative regulation of triglyceride biosynthetic process | ISS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0032792 | Negative regulation of CREB transcription factor activity | ISS | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA ISS | biological_process |
| GO:0042826 | Histone deacetylase binding | IEA | molecular_function |
| GO:0043276 | Anoikis | IEA | biological_process |
| GO:0045595 | Regulation of cell differentiation | ISS | biological_process |
| GO:0045721 | Negative regulation of gluconeogenesis | ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0055007 | Cardiac muscle cell differentiation | ISS | biological_process |
| GO:0071889 | 14-3-3 protein binding | IDA | molecular_function |
| GO:2000210 | Positive regulation of anoikis | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2649162798 | 0.7571958322 | 0.9598898170 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1233708859 |
| GSE13712_SHEAR | Up | 0.2185738523 |
| GSE13712_STATIC | Down | -0.1659342826 |
| GSE19018 | Down | -0.0079008804 |
| GSE19899_A1 | Up | 0.0328322490 |
| GSE19899_A2 | Up | 0.1594677863 |
| PubMed_21979375_A1 | Down | -0.0538752224 |
| PubMed_21979375_A2 | Down | -0.2166899330 |
| GSE35957 | Up | 0.1987028502 |
| GSE36640 | Up | 0.1069299979 |
| GSE54402 | Down | -0.0819141072 |
| GSE9593 | Up | 0.0906301312 |
| GSE43922 | Up | 0.8564883855 |
| GSE24585 | Down | -0.1711280173 |
| GSE37065 | Up | 0.4905632430 |
| GSE28863_A1 | Down | -0.1060983871 |
| GSE28863_A2 | Up | 0.0710365619 |
| GSE28863_A3 | Up | 0.2709822623 |
| GSE28863_A4 | Up | 0.0359678314 |
| GSE48662 | Up | 0.2257589732 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dabrafenib | DB08912 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-32-5p | MIMAT0000090 | MIRT028368 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT050012 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052414 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22418434 | Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance |
| 20528770 | In contrast, up-regulation of Nuak2 (NUAK family, SNF1-like kinase 2) and down-regulation of Lonp2 (Lon peptidase 2), Foxo3a (forkhead box O3a), Sod1 (copper/zinc superoxide dismutase) and Sesn1 (sestrin 1) in the kidneys of recuperated offspring suggest that protein homoeostasis and resistance to oxidative stress are compromised, leading to accelerated cellular senescence in these shorter-lived mice |
Entries Per Page
Displaying Page of
