| 27698927 | The cells consistently harbored concomitant mutations of CTNNB1 (Ser45Pro) and WT1 (Arg413Stop) thorough the cultivation |
| 27698927 | As with those evidence of senescence in advanced cell passages, expression of p21 and cyclin D1 increased when the expression of beta-catenin and its downstream protein, TCF, declined |
| 27642518 | In addition, circRNAs can oversee cellular metabolism and disorders such as diabetes mellitus through the regulation of insulin signaling as well as limit tumor progression through Wnt signaling and beta-catenin pathways |
| 27294914 | In addition, ginsenoside Rg1 decreased beta-catenin and c-Myc mRNA expression and enhanced the phosphorylation of GSK-3beta |
| 27294914 | Our findings indicated that ginsenoside Rg1 can improve the resistance of Sca-1(+) HSC/HPCs in a mouse model of d-galactose-induced aging through the suppression of oxidative stress and excessive activation of the Wnt/beta-catenin signaling pathway, and reduction of DNA damage response, p16(Ink4a)-Rb and p53-p21(Cip1/Waf1) signaling |
| 27129219 | HBP1 was also found to enhance p21 transcription by inhibiting Wnt/beta-catenin signaling |
| 27129219 | We identified histone methyltransferase EZH2, the catalytic subunit of polycomb repressive complex 2, as a target of Wnt/beta-catenin signaling |
| 27129219 | HBP1-mediated repression of EZH2 through Wnt/beta-catenin signaling decreased the level of trimethylation of histone H3 at lysine 27 of overall and specific histone on the p21 promoter, resulting in p21 transactivation |
| 26475718 | Wnt/beta-catenin signaling in bone marrow niche |
| 26475718 | Several signaling pathways (including Wnt/beta-catenin) regulate various aspects of stem cell growth, function and death in the BM niche |
| 26475718 | We review the role of the Wnt/beta-catenin pathway in the BM niche and its importance in stem cells |
| 26475718 | Relevant literature was identified by a PubMed search (1997-2014) of English-language literature by using the following keywords: BM niche, Wnt/beta-catenin signaling, osteoblast, osteoclast and bone disease |
| 26475718 | The Wnt/beta-catenin pathway regulates the stability of the beta-catenin proto-oncogene |
| 26475718 | The stabilized beta-catenin then translocates to the nucleus, forming a beta-catenin-TCF/LEF complex regulating the transcription of specific target genes |
| 26475718 | Aberrant Wnt/beta-catenin signaling and its downstream transcriptional regulators are observed in several malignant stem cells and human cancers |
| 26474698 | Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving beta-catenin signaling in hyperlipidemia |
| 26474698 | The rats were fed with high-fat diet for 8 weeks to establish a hyperlipidemic model, which showed an increase in plasma lipids, endothelium-derived MPO expression, endothelial senescence and endothelial dysfunction concomitant with a reduction in glycogen synthase kinase 3 beta (GSK-3beta) activity and phosphorylated beta-catenin (p-beta-catenin) level as well as an increase in beta-catenin and p53 levels within the endothelium |
| 26474698 | Consistent with the finding in vivo, ox-LDL-induced MPO expression and HUVECs senescence, accompanied by a decrease in GSK-3beta activity and p-beta-catenin level as well as an increase in HOCl content, beta-catenin and p53 levels; these phenomena were attenuated by MPO inhibitor |
| 26474698 | Replacement of ox-LDL with HOCl could also induce HUVECs senescence and activate the beta-catenin/p53 pathway |
| 26474698 | Based on these observations, we conclude that endothelium-derived MPO is upregulated in hyperlipidemic rats, which may contribute to the accelerated vascular endothelial senescence through a mechanism involving the beta-catenin/p53 pathway |
| 26472020 | However, ROS-induced miR-182 is regulated by beta-catenin, not by p53 |
| 26472020 | These findings suggest that ROS and p53 mutations may trigger a series of events, beginning with overexpressing miR-182 by ROS and beta-catenin, impairing the DNA damage response, promoting DNA instability, bypassing senescence and eventually leading to DNA instable tumors in FTSE cells |
| 26456654 | Different effects of resveratrol on early and late passage mesenchymal stem cells through beta-catenin regulation |
| 26456654 | In early passage MSCs expressing SIRT1, resveratrol decreased ERK and GSK-3beta phosphorylation, suppressing beta-catenin activity |
| 26456654 | In contrast, in late passage MSCs, which did not express SIRT1, resveratrol increased ERK and GSK-3beta phosphorylation, activating beta-catenin |
| 26456654 | We confirmed that SIRT1-deficient early passage MSCs treated with resveratrol lost their self-renewal potential and multipotency, and became senescent due to increased beta-catenin activity |
| 26010604 | Tumor irradiation led to dramatic upregulation of beta-catenin expression in tumor tissues, an effect that was mitigated in T2821 xenografts when ganetespib was combined with IR treatments |
| 26003288 | Canonical Wnt signaling influences cellular fate and proliferation through inhibition of Glycogen Synthase Kinase (GSK3) and the subsequent stabilization of its many substrates, most notably beta-Catenin, a transcriptional co-activator |
| 25798129 | Additionally, zonation and regeneration of the adrenal cortex are controlled by developmental signaling pathways, such as the sonic hedgehog, delta-like homolog 1, fibroblast growth factor, and WNT/beta-catenin pathways |
| 25777063 | The molecular mechanisms involve substrate competition of tau and beta-catenin for glycogen synthase kinase 3beta (GSK-3beta); activation of Akt; preservation of Bcl-2 and suppression of Bax, cytosolic cytochrome-c, and caspase-3 activity; and upregulation of unfolded protein response (UPR), i |
| 25728679 | Interestingly, Wnt7a induced an alternate senescence pathway, which was independent of beta-catenin, and distinct from that of classical oncogene-induced senescence mediated by the well-known p16(INK4a) and p19(ARF) pathways |
| 25645196 | BACKGROUND: The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects |
| 25645196 | However, mechanistic insight in how beta-catenin inhibits the Hh pathway is not known |
| 25645196 | FINDINGS: Here we show that beta-catenin stabilization by the glycogen synthase kinase 3 inhibitor lithium chloride (LiCl) reduced growth of primary hedgehog-driven MB tumor spheres from patched heterozygous mice (Ptch(+/-)) in vitro |
| 25645196 | Mechanistically, we show by co-immunoprecipitation and proximity ligation assay that stabilized beta-catenin physically interacts with Gli1, leading to Gli1 sequestration and inhibition of its transcriptional activity |
| 25645196 | CONCLUSION: We propose that beta-catenin stabilization increases its physical interaction with Gli1, leading to Gli1 degradation and inhibition of Hh signaling, thereby promoting tumor cell senescence and suppression of "tumor take" in mice |
| 25483308 | Electrophoretic mobility shift assay and RNA coimmunoprecipitation revealed CPEB2 interaction with beta-catenin and Ca(2+) /calmodulin-dependent protein kinase II (both established CPEB1 targets), indicating an overlap in RNA binding specificity between CPEB1 and CPEB2 |
| 25437011 | Wnt/beta-catenin signaling plays a functional role as a key regulator of self-renewal and differentiation in mesenchymal stem cells (MSCs), and thus Wnt/beta-catenin signaling and cellular senescence might be closely connected |
| 25437011 | In contrast, suppression of the Wnt pathway by treatment with dickkopf-1 (an antagonist of the Wnt coreceptor) and beta-catenin siRNA transfection promotes senescence in MSCs |
| 25427424 | SOX1 down-regulates beta-catenin and reverses malignant phenotype in nasopharyngeal carcinoma |
| 25427424 | BACKGROUND: Aberrant activation of the Wnt/beta-catenin signaling pathway is an important factor in the development of nasopharyngeal carcinoma (NPC) |
| 25427424 | Previous studies have demonstrated that the developmental gene sex-determining region Y (SRY)-box 1 (SOX1) inhibits cervical and liver tumorigenesis by interfering with the Wnt/beta-catenin signaling pathway |
| 25427424 | Notably, SOX1 was found to physically interact with beta-catenin and reduce its expression independent of proteasomal activity, leading to inhibition of Wnt/beta-catenin signaling and decreased expression of downstream target genes |
| 25427424 | CONCLUSIONS: SOX1 decreases the expression of beta-catenin in a proteasome-independent manner and reverses the malignant phenotype in NPC cells |
| 25241737 | The absence of SLIT/ROBO2 signaling leads to increased levels of nuclear beta-catenin |
| 25184156 | Interestingly, the levels of phosphorylated Akt and beta-catenin were significantly downregulated with treating the apoptotic inducing doses |
| 24853424 | Hyperactivation of the Wingless-type (Wnt)/beta-catenin pathway promotes tumor initiation, tumor growth and metastasis in various tissues |
| 24853424 | Although there is evidence for the involvement of Wnt/beta-catenin pathway activation in salivary gland tumors, the precise mechanisms are unknown |
| 24599132 | This review summarizes recent insights to the noncanonical functions of telomerase reverse transcriptase (TERT) catalytic subunit, in particular in cancer progression, and highlights two major signaling mechanisms involved in the cross-talk with TERT-the NF-kappaB and Wnt/beta-catenin pathways |
| 24481601 | Acid pulsing induced Dkk1-mediated senescence, which was directly linked to the ability of Dkk1 to antagonize the canonical Wnt/beta-catenin signaling |
| 24481601 | In healthy esophageal mucosa, Dkk1 expression was associated with low expression of transcriptionally active beta-catenin, while in reflux-esophagitis tissue, Dkk1 overexpression correlated with increased senescence-associated beta-galactosidase activity and p16 upregulation |
| 24481601 | The data indicate that, in human reflux esophagitis, Dkk1 functions as a secreted growth inhibitor by suppressing Wnt/beta-catenin signaling and promoting cellular senescence |
| 24296714 | DM EPCs also exhibited higher levels of GSK3beta activity resulting in increased levels of phosphorylated beta-catenin |
| 24286133 | Conversely, the suppression of TNF-alpha promoter activity using a beta-catenin small interfering RNA was evident |
| 24130040 | Previous studies have demonstrated that Wnt/beta-catenin signaling plays an important role in stem cell senescence |
| 24130040 | We have found that Wnt/beta-catenin signaling and the p53/p21 pathway were significantly hyperactivated in senescent SLE BM-MSCs |
| 24130040 | Treatment with 100 ng/mL Dickkopf-1 (DKK1), a Wnt/beta-catenin signaling inhibitor or beta-catenin siRNA for 48 h could reverse the senescent features of SLE BM-MSCs |
| 24130040 | In summary, our study indicated that Wnt/beta-catenin signaling may play a critical role in the senescence of SLE BM-MSCs through the p53/p21 pathway |
| 23474484 | Ku70 functions in addition to nonhomologous end joining in pancreatic beta-cells: a connection to beta-catenin regulation |
| 23474484 | This augmented beta-cell proliferation was accompanied by an increased beta-catenin level, which we propose to be responsible for this phenotype |
| 23272224 | The present study was designed to determine whether the beta-catenin destruction complex (BCDC), known to integrate the action of various growth factors and cytokines, would represent a suitable target to inhibit the activity of SASP components |
| 23272224 | For this, we carried out experiments to determine the effect of drug-induced senescence on secretion of SASP, beta-catenin transactivation, and the relationship between these processes |
| 23174937 | CTNNB1 mutation was detected in a serous tumor |
| 23124852 | Wnt/beta-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production |
| 23124852 | Recent studies have demonstrated that the Wnt/beta-catenin signaling plays an important role in stem cell aging |
| 23124852 | However, the mechanisms of cell senescence induced by Wnt/beta-catenin signaling are still poorly understood |
| 23124852 | Our preliminary study has indicated that activated Wnt/beta-catenin signaling can induce MSC aging |
| 23124852 | In this study, we reported that the Wnt/beta-catenin signaling was a potent activator of reactive oxygen species (ROS) generation in MSCs |
| 23124852 | After scavenging ROS with N-acetylcysteine, Wnt/beta-catenin signaling-induced MSC aging was significantly attenuated and the DNA damage and the expression of p16(INK4A), p53, and p21 were reduced in MSCs |
| 23124852 | These results indicated that the Wnt/beta-catenin signaling could induce MSC aging through promoting the intracellular production of ROS, and ROS may be the main mediators of MSC aging induced by excessive activation of Wnt/beta-catenin signaling |
| 22795190 | Wnt/beta-catenin signaling is downregulated but restored by nutrition interventions in the aged heart in mice |
| 22795190 | The Wnt/beta-catenin signaling pathway has emerged as a key player in cellular aging in recent years |
| 22795190 | Contrary to the hypothesis, our study shows that the Wnt/beta-catenin signaling is down-regulated in aged heart in mice |
| 22795190 | Nutrition treatment, with calorie restriction and Resveratrol supplementation, known to retard aging, opposes heart aging by restoring Wnt/beta-catenin signaling level in the old heart |
| 22795190 | In addition, the expression of beta-catenin gene, a key regulator of the Wnt/beta-catenin signaling pathway, decreases up to 3-fold in aged heart, but is restored to levels found in young heart with methods of nutrition intervention |
| 22767186 | SOX1 functions as a tumor suppressor by antagonizing the WNT/beta-catenin signaling pathway in hepatocellular carcinoma |
| 22767186 | Furthermore, we used glutathione S-transferase pull-down, co-immunoprecipitation, and confocal microscopy to demonstrate that SOX1 could interact with beta-catenin but not with the beta-catenin/TCF complex |
| 22294024 | Cilostazol significantly reduced the expression of type II collagen and stimulated the accumulation of beta-catenin in primary rat articular chondrocytes |
| 21816908 | Mechanistically, Wnt5a antagonizes canonical Wnt/beta-catenin signaling and induces cellular senescence by activating the histone repressor A/promyelocytic leukemia senescence pathway |
| 21707762 | Study on the roles of beta-catenin in hydrogen peroxide-induced senescence in human skin fibroblasts |
| 21707762 | Previous studies showed that beta-catenin can regulate FoxO3a and this association was enhanced in cells exposed to oxidative stress |
| 21707762 | It has also been reported that beta-catenin can regulate some senescence-related proteins |
| 21707762 | We propose that beta-catenin may play a crucial role in senescence of normal human primary skin fibroblasts (NHSFs) |
| 21707762 | Here, we explored the roles and mechanisms of beta-catenin on H(2)O(2)-induced senescence in NHSFs |
| 21707762 | Overexpression of beta-catenin in NHSFs led to a marked delay of many senescent phenotypes induced by H(2)O(2) |
| 21707762 | Furthermore, overexpression of beta-catenin in NHSFs can antagonise the alteration of reactive oxygen species accumulation and some senescence-related proteins expression induced by H(2)O(2) treatment |
| 21707762 | Our data demonstrated that beta-catenin can protect NHSFs from H(2)O(2)-induced premature senescence by alleviating oxidative stress and regulating some senescence-related molecules |
| 21695255 | Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/beta-catenin and PTEN |
| 21695255 | However, the role of WNT/beta-catenin and PTEN/AKT signaling in the etiology and/or progression of this disease is currently unclear |
| 21695255 | In this report we show that mice with a gain-of-function mutation in beta-catenin that leads to dysregulated nuclear accumulation of beta-catenin expression in the ovarian surface epithelium (OSE) cells develop indolent, undifferentiated tumors with both mesenchymal and epithelial characteristics |
| 21695255 | Combining dysregulated beta-catenin with homozygous deletion of PTEN in the OSE resulted in development of significantly more aggressive tumors, which was correlated with inhibition of p53 expression and cellular senescence |
| 21695255 | Induced expression of both mTOR kinase, a master regulator of proliferation, and phosphorylation of its downstream target, S6Kinase was also observed in both the indolent and aggressive mouse tumors, as well as in human OEA with nuclear beta-catenin accumulation |
| 21695255 | Ectopic allotransplants of the mouse ovarian tumor cells with a gain-of-function mutation in beta-catenin and PTEN deletion developed into tumors with OEA histology, the growth of which were significantly inhibited by oral rapamycin treatment |
| 21695255 | These studies demonstrate that rapamycin might be an effective therapeutic for human ovarian endometrioid patients with dysregulated Wnt/beta-catenin and Pten/PI3K signaling |
| 21678465 | Wnt/beta-catenin (hereafter called Wnt) signaling is a key inducer and regulator of joint development, and is involved in the formation of bone and cartilage |
| 20533544 | Enhancement of intervertebral disc cell senescence by WNT/beta-catenin signaling-induced matrix metalloproteinase expression |
| 20533544 | OBJECTIVE: To determine whether intervertebral disc (IVD) cells express beta-catenin and to assess the role of the WNT/beta-catenin signaling pathway in cellular senescence and aggrecan synthesis |
| 20533544 | METHODS: The expression of beta-catenin messenger RNA (mRNA) and protein in rat IVD cells was assessed by using several real-time reverse transcription-polymerase chain reaction, Western blot, immunohistochemical, and immunofluorescence analyses |
| 20533544 | The effect of WNT/beta-catenin on nucleus pulposus (NP) cells was examined by transfection experiments, an MTT assay, senescence-associated beta-galactosidase staining, a cell cycle analysis, and a transforming growth factor (TGFbeta)/bone morphogenetic protein (BMP) pathway-focused microarray analysis |
| 20533544 | RESULTS: We found that beta-catenin mRNA and protein were expressed in discs in vivo and that rat NP cells exhibited increased beta-catenin mRNA and protein upon stimulation with lithium chloride, a known activator of WNT signaling |
| 20533544 | Activation of WNT/beta-catenin signaling also regulated the expression of aggrecan |
| 20533544 | We also demonstrated that WNT/beta-catenin signaling induced the expression of matrix metalloproteinases (MMPs) and TGFbeta in NP cells |
| 20533544 | CONCLUSION: The activation of WNT/beta-catenin signaling promotes cellular senescence and may modulate MMP and TGFbeta signaling in NP cells |
| 20533544 | We hypothesize that the activation of WNT/beta-catenin signaling may lead to an increased breakdown of the matrix, thereby promoting IVD degeneration |
| 19938640 | Several molecular targeting therapies are described by activation and blocking distinct developmental signaling cascade elements, such as BRCA1, EGFR, hedgehog, Wnt/beta-catenin, and/or Notch pathways, which are frequently upregulated in cancer progenitor cells during the initiation and development of breast cancer |
| 19733540 | Although Wnt1 induced the activation of beta-catenin and the mTOR pathway, both hair follicle hyperproliferation and stem cell exhaustion were strictly dependent on mTOR function |
| 19733540 | These findings suggest that whereas activation of beta-catenin contributes to tumor growth, epithelial stem cells may be endowed with a protective mechanism that results in cell senescence upon the persistent stimulation of proliferative pathways that activate mTOR, ultimately suppressing tumor formation |
| 19407340 | We have previously shown that lithium, an inhibitor of glycogen synthase kinase (GSK)-3beta and activator of the Wnt/beta-catenin signaling pathway, induces an EC senescent-like phenotype |
| 18582478 | Up-regulation of protein L-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization |
| 18582478 | In this study, we demonstrated that glycogen synthase kinase-3 (GSK-3) and beta-catenin are involved in the regulation of PIMT expression |
| 18582478 | As expected, GSK-3 inhibition led to an increase of phosphorylated GSK-3beta (Ser9) and to beta-catenin accumulation |
| 18582478 | Additionally, inhibition by siRNA of GSK-3 and beta-catenin modulated the expression of the PIMT in accordance with GSK-3 pharmacological inhibition |
| 18582478 | Valproic acid, an antiepileptic drug with mood-stabilizing properties, up-regulated phospho-GSK-3beta (Ser9), beta-catenin and PIMT levels similarly to lithium |
| 18582478 | This study reports that PIMT expression is up-regulated by GSK-3 inhibition and beta-catenin stabilization upon treatments with lithium and valproic acid |
| 17145814 | The expression of p16, beta-catenin, and Gli1 and the in vivo methylation status of the p16 gene were also analyzed in serial sections of colonic precancerous lesions |
| 15111320 | Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells |
| 15111320 | The functional consequences of up-regulation of beta-catenin as a transcription factor are complex in different tumors |
| 15111320 | To clarify roles during squamous differentiation (SqD) of endometrial carcinoma (Em Ca) cells, we investigated expression of beta-catenin, as well as cyclin D1, p53, p21WAF1, and PML (promyelocytic leukemia) in 80 cases of Em Ca with SqD areas, in comparison with cell proliferation determined with reference to Ki-67 antigen positivity |
| 15111320 | In clinical cases, nuclear beta-catenin accumulation was more frequent in SqD areas, being positively linked with expression of cyclin D1, p53, and p21WAF1, and inversely with Ki-67 and PML immunoreactivity |
| 15111320 | Significant correlations of nuclear beta-catenin, cyclin D1, p53, and p21WAF1 were noted between SqD and the surrounding carcinoma lesions |
| 15111320 | The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs |
| 15111320 | Moreover, overexpressed beta-catenin could activate transcription from p14ARF and cyclin D1 promoters, in a TCF4-dependent manner |
| 15111320 | However, overexpression of beta-catenin alone is not sufficient for development of a squamoid phenotype in Em Ca cells, suggesting that nuclear accumulation is an initial signal for trans-differentiation |
| 11280772 | Stabilized beta-catenin immortalizes colonic epithelial cells |
| 11280772 | The majority of colonic neoplasias contain mutations in either the adenomatous polyposis coli or the beta-catenin (beta-cat) gene, both of which result in elevated levels of cytoplasmic beta-cat |
| 11280772 | IMCE neo cells at nonpermissive conditions underwent extensive apoptosis, an effect that was blocked by the expression of deltaN89 beta-catenin |
