HCSGD entry for PDIK1L
1. General information
| Official gene symbol | PDIK1L |
|---|---|
| Entrez ID | 149420 |
| Gene full name | PDLIM1 interacting kinase 1 like |
| Other gene symbols | CLIK1L STK35L2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2514205083 | 0.5618129592 | 0.9412088181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2748765561 |
| GSE13712_SHEAR | Down | -0.1758449027 |
| GSE13712_STATIC | Up | 0.0270217874 |
| GSE19018 | Down | -0.1038349276 |
| GSE19899_A1 | Up | 0.3075073445 |
| GSE19899_A2 | Up | 0.1499814903 |
| PubMed_21979375_A1 | Up | 0.0664172529 |
| PubMed_21979375_A2 | Up | 0.1570778831 |
| GSE35957 | Down | -0.0767234464 |
| GSE36640 | Down | -0.0288114389 |
| GSE54402 | Up | 0.2274013808 |
| GSE9593 | Down | -0.5386012582 |
| GSE43922 | Up | 0.3525814154 |
| GSE24585 | Up | 0.0541845395 |
| GSE37065 | Down | -0.0617245944 |
| GSE28863_A1 | Up | 0.1433869938 |
| GSE28863_A2 | Up | 0.4037375669 |
| GSE28863_A3 | Down | -0.4217235462 |
| GSE28863_A4 | Up | 0.0242582839 |
| GSE48662 | Down | -0.2791190160 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT003816 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016218 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024137 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040545 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049117 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050716 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 | |||
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26085373 | By using this approach, we identified casein kinase 2 (CK2) as a pro-senescent target |
| 25064843 | PLD2 overexpression increased protein kinase CK2 (also known as casein kinase 2) (CK2) activity |
| 23766372 | REGgamma deficiency promotes premature aging via the casein kinase 1 pathway |
| 23766372 | Here, we demonstrate that REGgamma-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK) 1delta and p53 |
| 21331045 | Here we show that casein kinase Ialpha (CKIalpha), a component of the beta-catenin-destruction complex, is a critical regulator of the Wnt signalling pathway |
| 16873060 | Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors |
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