HCSGD entry for CTLA4

1. General information

Official gene symbolCTLA4
Entrez ID1493
Gene full namecytotoxic T-lymphocyte-associated protein 4
Other gene symbolsCD CD152 CELIAC3 CTLA-4 GRD4 GSE IDDM12
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006955Immune responseIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIMPbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0030889Negative regulation of B cell proliferationIMPbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0042130Negative regulation of T cell proliferationIEAbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0045334Clathrin-coated endocytic vesicleIDAcellular_component
GO:0045590Negative regulation of regulatory T cell differentiationIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050777Negative regulation of immune responseIEAbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72261677370.88098610620.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0211927533
GSE13712_SHEARDown-0.0506635023
GSE13712_STATICUp0.0893570928
GSE19018Down-0.0534755069
GSE19899_A1Up0.0195577984
GSE19899_A2Up0.0270696810
PubMed_21979375_A1Up0.3555674268
PubMed_21979375_A2Down-0.0539752251
GSE35957Up0.0490962609
GSE36640Up0.0930901657
GSE54402Up0.0088885573
GSE9593Down-0.0992638959
GSE43922Up0.0166769029
GSE24585Up0.0091941696
GSE37065Down-0.0936040893
GSE28863_A1Up0.1218137658
GSE28863_A2Up0.1963944250
GSE28863_A3Up0.0771757350
GSE28863_A4Down-0.0642374724
GSE48662Up0.1926602354

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IpilimumabDB06186 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT004436MicroarrayFunctional MTI (Weak)19193853
hsa-miR-92a-3pMIMAT0000092MIRT049319CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT00006461hsa-miR-155{flow cytometry}{overexpression by miRNA precursor transfection}20673989
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27102208Low programmed death 1 and cytotoxic T-lymphocyte-associated antigen 4 expression detected on T-cell clones infers that these cells are not exhausted but suggests that there would be a suboptimal response to immune checkpoint blockade in MM
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