HCSGD entry for CTGF

1. General information

Official gene symbolCTGF
Entrez ID1490
Gene full nameconnective tissue growth factor
Other gene symbolsCCN2 HCS24 IGFBP8 NOV2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001503OssificationIEAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0001558Regulation of cell growthIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0001968Fibronectin bindingIEAmolecular_function
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005520Insulin-like growth factor bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005801Cis-Golgi networkIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008201Heparin bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0008544Epidermis developmentTASbiological_process
GO:0009611Response to woundingTASbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010260Organ senescenceIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010942Positive regulation of cell deathIEAbiological_process
GO:0016477Cell migrationIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0032330Regulation of chondrocyte differentiationIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIEAbiological_process
GO:0034059Response to anoxiaIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0035988Chondrocyte proliferationIEAbiological_process
GO:0043200Response to amino acidIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045597Positive regulation of cell differentiationIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050867Positive regulation of cell activationIEAbiological_process
GO:0051385Response to mineralocorticoidIEAbiological_process
GO:0051496Positive regulation of stress fiber assemblyIDAbiological_process
GO:0060401Cytosolic calcium ion transportIEAbiological_process
GO:0060452Positive regulation of cardiac muscle contractionIEAbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0070278Extracellular matrix constituent secretionIEAbiological_process
GO:0070318Positive regulation of G0 to G1 transitionIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070542Response to fatty acidIEAbiological_process
GO:0072593Reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82920284560.00429577900.99999024730.1334937426

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3987664600
GSE13712_SHEARUp0.6890184169
GSE13712_STATICDown-0.0731687377
GSE19018Down-0.2038056339
GSE19899_A1Down-0.7568638950
GSE19899_A2Down-1.0825106050
PubMed_21979375_A1Down-1.4757457885
PubMed_21979375_A2Down-0.9987206339
GSE35957Up0.7636726258
GSE36640Up0.1024311880
GSE54402Down-1.4327168174
GSE9593Up0.6360869542
GSE43922Down-0.6364210912
GSE24585Up0.0324808887
GSE37065Down-0.5047901287
GSE28863_A1Down-0.2910762417
GSE28863_A2Down-0.1550348956
GSE28863_A3Up0.4032655182
GSE28863_A4Down-0.4094894163
GSE48662Down-0.1828207457

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002604MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002604MicroarrayFunctional MTI (Weak)18668037
hsa-miR-18a-5pMIMAT0000072MIRT004174Western blot//Microarray//Northern blot//Luciferase reporter assayFunctional MTI16331254
hsa-miR-18a-5pMIMAT0000072MIRT004174Luciferase reporter assayFunctional MTI19233176
hsa-miR-26a-5pMIMAT0000082MIRT004338Western blotNon-Functional MTI18713946
hsa-miR-205-5pMIMAT0000266MIRT006936Western blotFunctional MTI23056551
hsa-miR-145-5pMIMAT0000437MIRT007247Luciferase reporter assayFunctional MTI23390502
hsa-miR-375MIMAT0000728MIRT019692MicroarrayFunctional MTI (Weak)20215506
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-19a-3pMIMAT0000073NAhsa-miR-19a20305691
hsa-miR-19b-3pMIMAT0000074NAhsa-miR-19b20305691
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23155386Expression of apolipoprotein J (Apo J), connective tissue growth factor (CTGF), fibronectin, and laminin were examined by real-time PCR, western blot, or ELISA experiments
23155386Exposure to 8% of CSE markedly increased the number of SA-ss-Gal positive cells to up to 82%, and the mRNA expression of Apo J, CTGF, and fibronectin by approximately 3-4 fold
23155386Treatment with 8% of CSE also increased the protein expression of Apo J and CTGF and the secretion of fibronectin and laminin
22319624Omega-6 increased fibronectin and connective tissue growth factor synthesis, as well as the amount of secreted fibronectin
22319624H(2)O(2) stimulation of plasminogen activator inhibitor 1 and connective tissue growth factor was repressed by both fatty acids
19730126Postinfarct cardiac remodeling was associated with increased atrial natriuretic peptide, interleukin-6 and connective tissue growth factor mRNA expressions, as well as three-fold increased cardiomyocyte senescence, measured as cardiac p16 mRNA expression
19730126Levosimendan also ameliorated MI-induced atrial natriuretic peptide, IL-6, and connective tissue growth factor overexpression as well as MI-induced disturbances in calcium-handling proteins (SERCA2, Na-Ca exchanger) without changes in diabetic status or systemic blood pressure
19171648Expression of senescence-associated genes (apolipoprotein J [Apo J], connective tissue growth factor [CTGF], fibronectin, and SM22) was examined by real-time PCR and induction of signal transduction proteins (p21, p16, and pRb) by Western blot analysis
19171648RESULTS: H(2)O(2) markedly increased the number of SA-beta-Gal-positive cells to up to 89% and the expression of Apo J, CTGF, fibronectin, and SM22 by approximately three to fourfold
15610763Pyruvate dehydrogenase kinase 3 (Pdk3) and connective tissue growth factor (Ctgf) were up-regulated and hyaluronan synthase 3 (Has3) down-regulated under both conditions
15147944Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway
15147944Proteome analysis data demonstrated that connective tissue growth factor (CTGF) is an age-associated protein
15147944Up-regulation of CTGF expression in senescent cells was further confirmed by Western blotting and RT-PCR
15147944We postulate that CTGF expression is controlled, in part, by transforming growth factor-beta (TGF-beta), in view of the high levels of TGF-beta isoforms as well as type I and II receptors detected only in late PDL of HDF cells
15147944As expected, CTGF expression and Smad protein phosphorylation were dramatically increased up to observed levels in normal replicative senescent cells
15147944In vivo experiments disclosed that CTGF, pSmad, and p53 were constitutively expressed at basal levels in up to 18-month-old rat liver, and expression was significantly up-regulated in 24-month-old rat tissue
15147944In view of both in vitro and in vivo data, we propose that the TGF-beta/Smad pathway functions in the induction of CTGF, a novel biomarker protein of cellular senescence in human fibroblasts
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