HCSGD entry for HFE2
1. General information
| Official gene symbol | HFE2 |
|---|---|
| Entrez ID | 148738 |
| Gene full name | hemochromatosis type 2 (juvenile) |
| Other gene symbols | HFE2A HJV JH RGMC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0015026 | Coreceptor activity | IEA | molecular_function |
| GO:0030509 | BMP signaling pathway | IEA | biological_process |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0055072 | Iron ion homeostasis | IDA IEA IGI | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6887237339 | 0.8451470233 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0971481308 |
| GSE13712_SHEAR | Down | -0.1231937861 |
| GSE13712_STATIC | Down | -0.0529055412 |
| GSE19018 | Up | 0.1311936173 |
| GSE19899_A1 | Up | 0.1587824364 |
| GSE19899_A2 | Down | -0.0203208122 |
| PubMed_21979375_A1 | Down | -0.1429635366 |
| PubMed_21979375_A2 | Down | -0.1646837890 |
| GSE35957 | Down | -0.0655656143 |
| GSE36640 | Up | 0.1196886401 |
| GSE54402 | Down | -0.0256016973 |
| GSE9593 | Down | -0.1008965662 |
| GSE43922 | Up | 0.0231708843 |
| GSE24585 | Up | 0.1171003485 |
| GSE37065 | Down | -0.0516454889 |
| GSE28863_A1 | Up | 0.0539640670 |
| GSE28863_A2 | Up | 0.1408259124 |
| GSE28863_A3 | Up | 0.2976086330 |
| GSE28863_A4 | Up | 0.0148778454 |
| GSE48662 | Down | -0.0142577846 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23169885 | Similarly, RPE cells from hemojuvelin (Hjv)-knockout mice, another model of hemochromatosis, also had increased expression of GLUTs, HDACs, and DNMTs |
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