HCSGD entry for NKX2-5

1. General information

Official gene symbolNKX2-5
Entrez ID1482
Gene full nameNK2 homeobox 5
Other gene symbolsCHNG5 CSX CSX1 HLHS2 NKX2.5 NKX2E NKX4-1 VSD3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMP ISSbiological_process
GO:0001104RNA polymerase II transcription cofactor activityIEAmolecular_function
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001570VasculogenesisISSbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0003148Outflow tract septum morphogenesisIMPbiological_process
GO:0003161Cardiac conduction system developmentIMPbiological_process
GO:0003166Bundle of His developmentIEAbiological_process
GO:0003168Purkinje myocyte differentiationIEAbiological_process
GO:0003211Cardiac ventricle formationIEAbiological_process
GO:0003221Right ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0003278Apoptotic process involved in heart morphogenesisIEAbiological_process
GO:0003285Septum secundum developmentIMPbiological_process
GO:0003342Proepicardium developmentIEAbiological_process
GO:0003350Pulmonary myocardium developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IMPmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexICcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0007512Adult heart developmentIMPbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0010667Negative regulation of cardiac muscle cell apoptotic processIMPbiological_process
GO:0010735Positive regulation of transcription via serum response element bindingISSbiological_process
GO:0010736Serum response element bindingISSmolecular_function
GO:0010765Positive regulation of sodium ion transportISSbiological_process
GO:0010832Negative regulation of myotube differentiationIMPbiological_process
GO:0030097HemopoiesisISSbiological_process
GO:0030154Cell differentiationISSbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0030878Thyroid gland developmentIMPbiological_process
GO:0035050Embryonic heart tube developmentISSbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045214Sarcomere organizationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIMPbiological_process
GO:0045823Positive regulation of heart contractionISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IGI IMP ISSbiological_process
GO:0046982Protein heterodimerization activityISSmolecular_function
GO:0048536Spleen developmentIMP ISSbiological_process
GO:0051891Positive regulation of cardioblast differentiationISSbiological_process
GO:0055005Ventricular cardiac myofibril assemblyIEAbiological_process
GO:0055007Cardiac muscle cell differentiationISSbiological_process
GO:0055008Cardiac muscle tissue morphogenesisIMPbiological_process
GO:0055014Atrial cardiac muscle cell developmentISSbiological_process
GO:0055015Ventricular cardiac muscle cell developmentISSbiological_process
GO:0055117Regulation of cardiac muscle contractionISSbiological_process
GO:0060037Pharyngeal system developmentISSbiological_process
GO:0060038Cardiac muscle cell proliferationIEAbiological_process
GO:0060043Regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060261Positive regulation of transcription initiation from RNA polymerase II promoterISSbiological_process
GO:0060347Heart trabecula formationIEAbiological_process
GO:0060412Ventricular septum morphogenesisIMPbiological_process
GO:0060413Atrial septum morphogenesisIMPbiological_process
GO:0060928Atrioventricular node cell developmentIEAbiological_process
GO:0060929Atrioventricular node cell fate commitmentIEAbiological_process
GO:0060971Embryonic heart tube left/right pattern formationIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayISSbiological_process
GO:1901387Positive regulation of voltage-gated calcium channel activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45665918470.84827156260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1031928441
GSE13712_SHEARDown-0.1781188881
GSE13712_STATICUp0.0267253131
GSE19018Up0.0191164511
GSE19899_A1Up0.0034291521
GSE19899_A2Up0.0332661259
PubMed_21979375_A1Down-0.0272795756
PubMed_21979375_A2Down-0.2644269454
GSE35957Up0.1603304548
GSE36640Up0.1787548461
GSE54402Up0.1964081879
GSE9593Down-0.0627712937
GSE43922Up0.0308559289
GSE24585Down-0.1068468708
GSE37065Down-0.0187950419
GSE28863_A1Down-0.0069127224
GSE28863_A2Up0.1952028823
GSE28863_A3Up0.3821483674
GSE28863_A4Up0.1432652363
GSE48662Up0.4247755203

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030022MicroarrayFunctional MTI (Weak)19088304
hsa-miR-615-3pMIMAT0003283MIRT039794CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043120CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050106CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.