HCSGD entry for CSNK2B

1. General information

Official gene symbolCSNK2B
Entrez ID1460
Gene full namecasein kinase 2, beta polypeptide
Other gene symbolsCK2B CK2N CSK2B G5A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005956Protein kinase CK2 complexIEA NAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0016310PhosphorylationTASbiological_process
GO:0019887Protein kinase regulator activityIEA NASmolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0031519PcG protein complexIDAcellular_component
GO:0032927Positive regulation of activin receptor signaling pathwayIMPbiological_process
GO:0033211Adiponectin-activated signaling pathwayIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043537Negative regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0043623Cellular protein complex assemblyNASbiological_process
GO:0045859Regulation of protein kinase activityNASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050790Regulation of catalytic activityNASbiological_process
GO:0051101Regulation of DNA bindingNASbiological_process
GO:0061154Endothelial tube morphogenesisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17887891800.86950888260.82899036971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4589957672
GSE13712_SHEARDown-0.3990195476
GSE13712_STATICDown-0.1513554958
GSE19018Up0.2510314975
GSE19899_A1Up0.2454451940
GSE19899_A2Up0.2824754599
PubMed_21979375_A1Up0.4192145637
PubMed_21979375_A2Up0.3155176225
GSE35957Down-0.3965065278
GSE36640Up0.1483604205
GSE54402Up0.3346175686
GSE9593Up0.0149099494
GSE43922Up0.1398235291
GSE24585Up0.1524860037
GSE37065Down-0.0689523035
GSE28863_A1Up0.0789859784
GSE28863_A2Up0.0739242621
GSE28863_A3Down-0.0202698186
GSE28863_A4Down-0.1717636100
GSE48662Down-0.3211488278

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26703243Importantly, purified conventional PKC (cPKC) and atypical PKC (aPKC) enzymes enhanced CK2 activity and phosphorylated serines 194 and 277 within CK2alpha as well as serine 148 within CK2beta
7160623Total casein and phosvitin kinase activity did not change in the course of in vitro cell aging
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