HCSGD entry for E2F7

1. General information

Official gene symbolE2F7
Entrez ID144455
Gene full nameE2F transcription factor 7
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0001047Core promoter bindingIDA IEAmolecular_function
GO:0001890Placenta developmentISSbiological_process
GO:0002040Sprouting angiogenesisIEA IMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEA IMPmolecular_function
GO:0003714Transcription corepressor activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEA IMPbiological_process
GO:0030330DNA damage response, signal transduction by p53 class mediatorIDAbiological_process
GO:0032466Negative regulation of cytokinesisIEA ISSbiological_process
GO:0032877Positive regulation of DNA endoreduplicationIEA ISSbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0060707Trophoblast giant cell differentiationIEA ISSbiological_process
GO:0060718Chorionic trophoblast cell differentiationIEA ISSbiological_process
GO:0070365Hepatocyte differentiationIEA ISSbiological_process
GO:0071930Negative regulation of transcription involved in G1/S transition of mitotic cell cycleIDAbiological_process
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00025815890.94190387900.04448366011.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.6079243265
GSE13712_SHEARUp1.1913812135
GSE13712_STATICUp0.0833204200
GSE19018Up0.0633724602
GSE19899_A1Up2.4392372611
GSE19899_A2Up1.1821662751
PubMed_21979375_A1Up2.4370131844
PubMed_21979375_A2Up1.2042637753
GSE35957Down-1.1259949890
GSE36640Up0.1429771420
GSE54402Up2.1819015366
GSE9593Down-0.6786586806
GSE43922Up2.6232804659
GSE24585Up0.3509139635
GSE37065Down-0.0060510721
GSE28863_A1Down-0.1358722800
GSE28863_A2Up0.5026013855
GSE28863_A3Up0.2917274869
GSE28863_A4Up0.2432590226
GSE48662Down-0.4376644376

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26a-5pMIMAT0000082MIRT007177ChIP-seq//Immunoblot//Immunofluorescence//Functional MTI (Weak)23096114
hsa-miR-125a-5pMIMAT0000443MIRT021284SequencingFunctional MTI (Weak)20371350
hsa-miR-9-5pMIMAT0000441MIRT021444MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT022069MicroarrayFunctional MTI (Weak)17612493
hsa-miR-10a-5pMIMAT0000253MIRT025622SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027213SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT032071SequencingFunctional MTI (Weak)20371350
hsa-miR-125b-5pMIMAT0000423MIRT045917CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052179CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22802529The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
22802529We identify the atypical E2F family member E2F7 as the only E2F transcription factor potently up-regulated during oncogene-induced senescence, a setting where it acts in response to p53 as a direct transcriptional target
22802529Once induced, E2F7 binds and represses a series of E2F target genes and cooperates with RB to efficiently promote cell cycle arrest and limit oncogenic transformation
22802529Disruption of RB triggers a further increase in E2F7, which induces a second cell cycle checkpoint that prevents unconstrained cell division despite aberrant DNA replication
22802529Mechanistically, E2F7 compensates for the loss of RB in repressing mitotic E2F target genes
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