HCSGD entry for CSF3

1. General information

Official gene symbolCSF3
Entrez ID1440
Gene full namecolony stimulating factor 3 (granulocyte)
Other gene symbolsC17orf33 CSF3OS GCSF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005125Cytokine activityIDA IEA NASmolecular_function
GO:0005130Granulocyte colony-stimulating factor receptor bindingTASmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006955Immune responseIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayNASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0030838Positive regulation of actin filament polymerizationIDAbiological_process
GO:0030851Granulocyte differentiationNASbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0042993Positive regulation of transcription factor import into nucleusIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071345Cellular response to cytokine stimulusIDAbiological_process
GO:1901215Negative regulation of neuron deathIEAbiological_process
GO:2000251Positive regulation of actin cytoskeleton reorganizationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00013687550.97215897190.03398773581.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5246705001
GSE13712_SHEARUp1.6245337149
GSE13712_STATICUp0.2254110792
GSE19018Up0.1668251137
GSE19899_A1Up0.8827846243
GSE19899_A2Up4.7397989550
PubMed_21979375_A1Up6.1476948627
PubMed_21979375_A2Up3.3287509580
GSE35957Down-0.0322879503
GSE36640Down-0.0799642028
GSE54402Up4.5153374580
GSE9593Down-0.1494863815
GSE43922Up0.9891122118
GSE24585Down-0.0337576382
GSE37065Up0.2065322186
GSE28863_A1Down-0.2117905048
GSE28863_A2Down-0.0277503792
GSE28863_A3Up0.5026788963
GSE28863_A4Up0.2109846895
GSE48662Up0.0343453192

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25239491METHODS: In this double-blind, randomized sham-controlled trial, subjects received subcutaneous injections of granulocyte colony-stimulating factor (10 mug/kg per day) for 5 days, followed by leukapheresis, and intramuscular administration of 50-400 million sorted CD133+ cells delivered into both legs
26202037Multiple courses of G-CSF in patients with decompensated cirrhosis: consistent mobilization of immature cells expressing hepatocyte markers and exploratory clinical evaluation
26202037Administration of granulocyte colony-stimulating factor (G-CSF) induces the circulation of BMCs in the peripheral blood
26202037A phase II prospective trial was carried out for evaluation of BMC mobilization induced by multiple courses of G-CSF in cirrhotic patients
26202037PATIENTS AND METHODS: Fifteen patients with advanced liver cirrhosis (Child-Pugh score >/=6 points) were enrolled and treated with a 3-day G-CSF course, administered at 3-month intervals for a total of four courses
26202037Telomere length was monitored to rule out early cell aging caused by G-CSF
26202037Treatment was well tolerated, with no severe adverse events and no significant telomere length shortening following G-CSF
26202037CONCLUSION: This study demonstrates that G-CSF can be safely administrated up to four times over a 1-year period in decompensated cirrhotic patients
22721583We adopted granulocyte colony-stimulating factor combined with CXCR4 antagonist AMD3100 to stimulate MSCs to release into blood circulation of the rats
2085206368-fold) compared to another cytokine combination (SCF, thrombopoietin, and granulocyte colony-stimulating factor), although the two cytokine combinations had a similar level of total mononucleated cell expansion ( approximately 10% difference)
18491948In this study, we evaluated the efficiency of the OP9/TPO coculture system to sustain long-term hematopoiesis of adult, granulocyte colony-stimulating factor mobilized human peripheral blood (PB) CD34(+) cells
18403392We show that granulocyte colony-stimulating factor mobilized peripheral blood contains cells which form colonies and have a similar fibroblastic morphology (termed CFU-F) to bone marrow mesenchymal stem cells
15880640Late MSCs also exhibited attenuated synthesis of the hematopoietic cytokines granulocyte colony-stimulating factor (G-CSF), leukemia inhibitory factor (LIF), and stem cell factor (SCF)
12542495Administration of G-CSF increased telomerase activity in CD34+ haematopoietic cells compared with controls
12542495In addition, G-CSF administration to five lymphoma patients after consecutive courses of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy, resulted in telomere length preservation or elongation, as opposed to marked attrition in patients who did not receive growth factors
12542495We conclude that the in vivo administration of G-CSF prevents or attenuates telomere attrition associated with chemotherapy administration
11953664Physiologic and pathologic consequences of granulocyte colony-stimulating factor deficiency
11953664Published studies have extended our understanding of granulocyte colony-stimulating factor deficiency
11953664In granulocyte colony-stimulating factor withdrawal in humans, apoptosis seems to account for the dramatic loss of neutrophils, but whether the apoptosis results from normal cellular aging processes or accelerated cell loss upon granulocyte colony-stimulating factor withdrawal is unclear
11953664In granulocyte colony-stimulating factor(-/-) mice, the introduction of bcl-2, an antiapoptotic gene product, did not affect the number of neutrophils in the circulation
11953664In an experimental model of the induction of antigranulocyte colony-stimulating factor antibodies, the animals appeared remarkably similar to granulocyte colony-stimulating factor(-/-) mice
11953664This finding confirms that at least some neutrophils are produced by granulocyte colony-stimulating factor-independent mechanisms and suggests that the antigranulocyte colony-stimulating factor antibodies reported in clinical studies before and after granulocyte colony-stimulating factor administration do not lead to similar consequences
8806439The expression of granulocyte colony-stimulating factor (G-CSF) was not affected by either cellular aging or the cell cycle; however, the amount of product secreted increased significantly in old cells, suggesting that G-CSF production is under posttranscriptional regulation
8806439Under conditions of IL-1 induction G-CSF and M-CSF expression levels were enhanced in both young and old cells
8806439Significant M-CSF product was detected in young cells but not in old cells, whereas G-CSF product increased dramatically in both types of cells
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