HCSGD entry for CSF1R

1. General information

Official gene symbolCSF1R
Entrez ID1436
Gene full namecolony stimulating factor 1 receptor
Other gene symbolsC-FMS CD115 CSF-1R CSFR FIM2 FMS HDLS M-CSF-R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005011Macrophage colony-stimulating factor receptor activityIEA IMPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEA ISSbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008283Cell proliferationIMPbiological_process
GO:0008284Positive regulation of cell proliferationIEA IMPbiological_process
GO:0008360Regulation of cell shapeIEA IMPbiological_process
GO:0009986Cell surfaceIEA ISScellular_component
GO:0016020MembraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIMPbiological_process
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0019955Cytokine bindingIDA IEA ISSmolecular_function
GO:0030097HemopoiesisIMPbiological_process
GO:0030224Monocyte differentiationTASbiological_process
GO:0030225Macrophage differentiationTASbiological_process
GO:0030316Osteoclast differentiationIEA ISSbiological_process
GO:0030335Positive regulation of cell migrationIEA ISSbiological_process
GO:0031529Ruffle organizationIEA ISSbiological_process
GO:0036006Cellular response to macrophage colony-stimulating factor stimulusIMPbiological_process
GO:0038145Macrophage colony-stimulating factor signaling pathwayIMP TASbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIEA ISSbiological_process
GO:0042803Protein homodimerization activityIEA ISSmolecular_function
GO:0043235Receptor complexIEA ISScellular_component
GO:0045087Innate immune responseIEAbiological_process
GO:0045124Regulation of bone resorptionISSbiological_process
GO:0045217Cell-cell junction maintenanceIMPbiological_process
GO:0046488Phosphatidylinositol metabolic processIEA ISSbiological_process
GO:0046777Protein autophosphorylationIDA IEAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEA ISSbiological_process
GO:0060603Mammary gland duct morphogenesisTASbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEA ISSbiological_process
GO:0071345Cellular response to cytokine stimulusISSbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIEA ISSbiological_process
GO:0090197Positive regulation of chemokine secretionIMPbiological_process
GO:2000147Positive regulation of cell motilityIMPbiological_process
GO:2000249Regulation of actin cytoskeleton reorganizationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20230452490.85122734700.86830370131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0175574035
GSE13712_SHEARUp0.1708913539
GSE13712_STATICUp0.1140675394
GSE19018Up0.0981964617
GSE19899_A1Up0.1617123618
GSE19899_A2Up0.3193133047
PubMed_21979375_A1Down-0.0935659637
PubMed_21979375_A2Down-0.0508256653
GSE35957Down-0.0028489949
GSE36640Down-0.2962018315
GSE54402Up0.7045794259
GSE9593Up0.0759894379
GSE43922Up0.0819379617
GSE24585Up0.1306668858
GSE37065Up0.0835120478
GSE28863_A1Down-0.0472215177
GSE28863_A2Up0.1932738755
GSE28863_A3Up0.1861486289
GSE28863_A4Up0.0395857087
GSE48662Down-0.7110394350

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ImatinibDB00619 APRD01028 | EXPT02967 | DB03261
SunitinibDB01268 DB07417
ABT-869DB06080 -
5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDEDB07167 -
6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONEDB07202 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.